TY - JOUR
T1 - Adjuvant therapy in elderly patients with breast cancer
AU - Biganzoli, Laura
AU - Aapro, Matti
AU - Balducci, Lodovico
AU - Crivellari, Diana
AU - Minisini, Alessandro
AU - Piccart, Martine
PY - 2004
Y1 - 2004
N2 - The elderly population has been neglected by the traditional approach to clinical breast cancer research. Elderly women have been underrepresented in breast cancer clinical trials, with the majority of studies being restricted to patients aged <70 years. Elderly patients frequently have comorbidities and/or impaired organ function. These facts may often lead to death from causes other than cancer, thus nullifying any possible benefit of adjuvant treatment; furthermore, they render extrapolation of standard treatment recommendations to the elderly potentially hazardous, particularly with respect to chemotherapy. Therefore, specific clinical trials are needed to investigate adjuvant treatments tailored for the heterogeneous older population.
AB - The elderly population has been neglected by the traditional approach to clinical breast cancer research. Elderly women have been underrepresented in breast cancer clinical trials, with the majority of studies being restricted to patients aged <70 years. Elderly patients frequently have comorbidities and/or impaired organ function. These facts may often lead to death from causes other than cancer, thus nullifying any possible benefit of adjuvant treatment; furthermore, they render extrapolation of standard treatment recommendations to the elderly potentially hazardous, particularly with respect to chemotherapy. Therefore, specific clinical trials are needed to investigate adjuvant treatments tailored for the heterogeneous older population.
KW - Comorbidities
KW - Functional status
KW - Geriatric assessment
KW - Toxicity
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M3 - Article
C2 - 15335450
AN - SCOPUS:12344335720
VL - 5
SP - 188
EP - 195
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
SN - 1526-8209
IS - 3
ER -