Adjuvant therapy in elderly patients with breast cancer

Laura Biganzoli, Matti Aapro, Lodovico Balducci, Diana Crivellari, Alessandro Minisini, Martine Piccart

Research output: Contribution to journalArticlepeer-review


The elderly population has been neglected by the traditional approach to clinical breast cancer research. Elderly women have been underrepresented in breast cancer clinical trials, with the majority of studies being restricted to patients aged <70 years. Elderly patients frequently have comorbidities and/or impaired organ function. These facts may often lead to death from causes other than cancer, thus nullifying any possible benefit of adjuvant treatment; furthermore, they render extrapolation of standard treatment recommendations to the elderly potentially hazardous, particularly with respect to chemotherapy. Therefore, specific clinical trials are needed to investigate adjuvant treatments tailored for the heterogeneous older population.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalClinical Breast Cancer
Issue number3
Publication statusPublished - 2004


  • Comorbidities
  • Functional status
  • Geriatric assessment
  • Toxicity

ASJC Scopus subject areas

  • Cancer Research


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