Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins

Davide Mangioni, Giacomo Grasselli, Chiara Abbruzzese, Antonio Muscatello, Andrea Gori, Alessandra Bandera

Research output: Contribution to journalArticle

Abstract

Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive therapy. A novel case of VZV pneumonia in an immunocompromised patient, treated successfully with intravenous VZIG in combination with acyclovir, is reported here.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalInternational Journal of Infectious Diseases
Volume85
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Human Herpesvirus 3
Chickenpox
Immunoglobulins
Pneumonia
Immunocompromised Host
Post-Exposure Prophylaxis
Acyclovir
Therapeutics
Mortality

Keywords

  • Immunocompromised host
  • Intensive care unit
  • Intravenous immunoglobulins
  • Pneumonia
  • Varicella zoster virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins. / Mangioni, Davide; Grasselli, Giacomo; Abbruzzese, Chiara; Muscatello, Antonio; Gori, Andrea; Bandera, Alessandra.

In: International Journal of Infectious Diseases, Vol. 85, 01.08.2019, p. 70-73.

Research output: Contribution to journalArticle

@article{2edb4aa4beb94f37b0ccc155f96acf08,
title = "Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins",
abstract = "Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive therapy. A novel case of VZV pneumonia in an immunocompromised patient, treated successfully with intravenous VZIG in combination with acyclovir, is reported here.",
keywords = "Immunocompromised host, Intensive care unit, Intravenous immunoglobulins, Pneumonia, Varicella zoster virus",
author = "Davide Mangioni and Giacomo Grasselli and Chiara Abbruzzese and Antonio Muscatello and Andrea Gori and Alessandra Bandera",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.ijid.2019.05.022",
language = "English",
volume = "85",
pages = "70--73",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "Elsevier",

}

TY - JOUR

T1 - Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins

AU - Mangioni, Davide

AU - Grasselli, Giacomo

AU - Abbruzzese, Chiara

AU - Muscatello, Antonio

AU - Gori, Andrea

AU - Bandera, Alessandra

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive therapy. A novel case of VZV pneumonia in an immunocompromised patient, treated successfully with intravenous VZIG in combination with acyclovir, is reported here.

AB - Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive therapy. A novel case of VZV pneumonia in an immunocompromised patient, treated successfully with intravenous VZIG in combination with acyclovir, is reported here.

KW - Immunocompromised host

KW - Intensive care unit

KW - Intravenous immunoglobulins

KW - Pneumonia

KW - Varicella zoster virus

UR - http://www.scopus.com/inward/record.url?scp=85067249409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067249409&partnerID=8YFLogxK

U2 - 10.1016/j.ijid.2019.05.022

DO - 10.1016/j.ijid.2019.05.022

M3 - Article

VL - 85

SP - 70

EP - 73

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -