Administration of a dietary supplement (N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: A randomized controlled trial

Mariangela Rondanelli, Annalisa Opizzi, Sebastiano Bruno Solerte, Rosita Trotti, Catherine Klersy, Roberta Cazzola

Research output: Contribution to journalArticle

Abstract

Many studies have found that N-oleyl-ethanolamine (NOE), a metabolite of N-oleyl-phosphatidylethanolamine (NOPE), and epigallocatechin-3-gallate (EGCG) inhibit food intake. The main aim of this study was to evaluate the efficacy of 2 months of administration of an oily NOPE-EGCG complex (85 mg NOPE and 50 mg EGCG per capsule) and its effect on compliance with diet in healthy, overweight people. Secondary end-points of the study were to compare body composition, metabolic parameters, sensation of appetite, depressive symptoms and severity of binge eating. Using a parallel-arm, double-blind, placebo-controlled design, 138 healthy, overweight women (106) and men (thirty-two) were randomly assigned to one of two groups: (1) the treatment group (seventy-one patients: fifty-three females, eighteen males) taking two capsules per day of an oral supplement or (2) the placebo group (sixty-seven patients: fifty-three females, fourteen males). Both groups observed a 3344 kJ/d energy restriction. All parameters were assessed both before onset and after 2 months on the supplement. Dropout was 6 % in the NOPE-EGCG group and 27 % in the placebo group (P

Original languageEnglish
Pages (from-to)457-464
Number of pages8
JournalBritish Journal of Nutrition
Volume101
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Appetite
  • Dietary adherence
  • Epigallocatechin-3-gallate
  • Insulin resistance
  • N-oleyl-phosphatidylethanolamine

ASJC Scopus subject areas

  • Medicine(all)
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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