Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery

V. Dousias, T. Stefos, I. Navrozoglou, I. Staikos, A. Ditto, E. Paraskevaidis

Research output: Contribution to journalArticle

Abstract

The purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer. Methods: The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10. Results: The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups. Conclusion: Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalClinical and Experimental Obstetrics and Gynecology
Volume32
Issue number2
Publication statusPublished - 2005

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Keywords

  • Anemia
  • Erythropoietin
  • Gynecological cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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