Abstract
We have used a BALB/c colonic adenocarcinoma (C-26) to evaluate the therapeutic potential of recombinant interleukin-2 (rIL-2) at high and low dosages in combination with or without lymphokine-activated killers (LAK) or tumor-specific, immune lymphocytes in either an adjuvant spontaneous or an artificial metastasis system. Most (≈80%) of the mice that underwent s.c. C-26 tumor excision were shown to die of spontaneous metastasis with lung involvement by 1-4 months after excision. Postsurgical systemic treatment with low-dose rIL-2 (3 × 104 U/day, i.p.) increased the survival rate to 31% as compared to 21% (not significant) in excised controls while administration of high-dose rIL-2 (8 × 104 U/day) led to 53% survival (P
Original language | English |
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Pages (from-to) | 28-36 |
Number of pages | 9 |
Journal | Cancer Immunology, Immunotherapy |
Volume | 31 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1990 |
ASJC Scopus subject areas
- Oncology
- Immunology
- Cancer Research