Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections

Nicasio Mancini, Lara Marrone, Nicola Clementi, Giuseppe A. Sautto, Massimo Clementi, Roberto Burioni

Research output: Contribution to journalArticle

Abstract

Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review describes the potential of several T-cell-based therapeutic approaches in the prophylaxis and treatment of infectious diseases with a particular focus on persistent viral infections and opportunistic fungal infections, as these mostly affect immunocompromised patients.

Original languageEnglish
Pages (from-to)665-682
Number of pages18
JournalFuture Microbiology
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • adoptive T-cell therapy
  • chimeric antigen receptor
  • fungal infections
  • immunocompromised patients
  • infectious diseases
  • T cell
  • T-cell receptor
  • viral infections

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Medicine(all)

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