Adrenal adenocarcinoma and empty sella syndrome in a 37-year-old woman

V. De Leo, G. Morgante, A. Ditto, A. La Marca

Research output: Contribution to journalArticlepeer-review


The case of a 37-year-old woman with secondary amenorrhea and clear signs of hyperandrogenism is reported. The patient underwent hormonal evaluation including circadian rhythm of cortisol, gonadotropin-releasing hormone/thyroid-stimulating hormone (GnRH/TRH) test, corticotropic-releasing hormone (CRH) test and dexamethasone suppression test. She also underwent pelvic and adrenal ultrasound examination, adrenal computed axial tomography (CAT) scan and cranial nuclear magnetic resonance (NMR). A mass about 10 cm in size was detected in the left adrenal region. The sella was empty and the pituitary displaced downward. Suspected adrenal adenocarcinoma was confirmed by histological examination after surgical removal of the mass. This case of interest for physicians because of the mixed androgen and cortisol secretion of the adenocarcinoma in a hyperprolactinemic patient with empty sella. Moreover, it suggests the need to investigate the adrenal gland in patients with hyperprolactinemia and hirsutism.

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalGynecological Endocrinology
Issue number4
Publication statusPublished - 1999


  • Adrenal adenocarcinoma
  • CRH and GnRH/TRH test
  • Empty sella
  • Hirsutism
  • Hyperprolactinemia

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynaecology


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