Vincristine, an antimitotic agent, is able to induce adrenocortical activation in normal rats. This stimulation is not immediate, but commences after a lag of about 8 hr, and lasts for 18 hr. In hypophysectomized rats, vincristine also induces a plasma corticosterone increase, which is statistically higher when compared with that obtained with ACTH replacement. Following chronic treatment (6 days) with vincristine, adrenocortical activation is still present. It is suggested that this antimitotic agent activates the hypothalamic hypophyseal adrenal axis, stimulating the adrenocortical gland directly, and that this stimulation, unlike ACTH response, is delayed and long lasting.
|Number of pages||7|
|Journal||Rassegna di Medicina Sperimentale|
|Publication status||Published - 1974|
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