Adrenalectomy reduces the risk of vertebral fractures in patients with monolateral adrenal incidentalomas and subclinical hypercortisolism

Antonio Stefano Salcuni, Valentina Morelli, Cristina Eller Vainicher, Serena Palmieri, Elisa Cairoli, Anna Spada, Alfredo Scillitani, Iacopo Chiodini

Research output: Contribution to journalArticle

Abstract

Objective: Subclinical hypercortisolism (SH) is associated with increased risk of vertebral fractures (VFx). The effect on bone following recovery from SH is unknown. Design: Of the 605 subjects consecutively referred for monolateral adrenal incidentalomas (AIs) to our outpatient clinics, 55 SH patients (recruited on the basis of the exclusion criteria) were enrolled. We suggested to all patients to undergo adrenalectomy, which was accepted by 32 patients (surgical group, age 61.3±8.1 years) and refused by 23 patients, who were followed with a conservative management (non-surgical group, age 65.4±7.1 years). Methods:We diagnosed SH in patients with serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST)O5.0 mg/dl or with greater than or equal to two criteria among 1 mg-DST >3.0 μg/dl, urinary free cortisol >70 μg/24 h and ACTH

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalEuropean Journal of Endocrinology
Volume174
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Cushing Syndrome
Adrenalectomy
Dexamethasone
Hydrocortisone
Age Groups
Ambulatory Care Facilities
Adrenocorticotropic Hormone
Adrenal incidentaloma
Bone and Bones
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Adrenalectomy reduces the risk of vertebral fractures in patients with monolateral adrenal incidentalomas and subclinical hypercortisolism",
abstract = "Objective: Subclinical hypercortisolism (SH) is associated with increased risk of vertebral fractures (VFx). The effect on bone following recovery from SH is unknown. Design: Of the 605 subjects consecutively referred for monolateral adrenal incidentalomas (AIs) to our outpatient clinics, 55 SH patients (recruited on the basis of the exclusion criteria) were enrolled. We suggested to all patients to undergo adrenalectomy, which was accepted by 32 patients (surgical group, age 61.3±8.1 years) and refused by 23 patients, who were followed with a conservative management (non-surgical group, age 65.4±7.1 years). Methods:We diagnosed SH in patients with serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST)O5.0 mg/dl or with greater than or equal to two criteria among 1 mg-DST >3.0 μg/dl, urinary free cortisol >70 μg/24 h and ACTH",
author = "Salcuni, {Antonio Stefano} and Valentina Morelli and Vainicher, {Cristina Eller} and Serena Palmieri and Elisa Cairoli and Anna Spada and Alfredo Scillitani and Iacopo Chiodini",
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T1 - Adrenalectomy reduces the risk of vertebral fractures in patients with monolateral adrenal incidentalomas and subclinical hypercortisolism

AU - Salcuni, Antonio Stefano

AU - Morelli, Valentina

AU - Vainicher, Cristina Eller

AU - Palmieri, Serena

AU - Cairoli, Elisa

AU - Spada, Anna

AU - Scillitani, Alfredo

AU - Chiodini, Iacopo

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective: Subclinical hypercortisolism (SH) is associated with increased risk of vertebral fractures (VFx). The effect on bone following recovery from SH is unknown. Design: Of the 605 subjects consecutively referred for monolateral adrenal incidentalomas (AIs) to our outpatient clinics, 55 SH patients (recruited on the basis of the exclusion criteria) were enrolled. We suggested to all patients to undergo adrenalectomy, which was accepted by 32 patients (surgical group, age 61.3±8.1 years) and refused by 23 patients, who were followed with a conservative management (non-surgical group, age 65.4±7.1 years). Methods:We diagnosed SH in patients with serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST)O5.0 mg/dl or with greater than or equal to two criteria among 1 mg-DST >3.0 μg/dl, urinary free cortisol >70 μg/24 h and ACTH

AB - Objective: Subclinical hypercortisolism (SH) is associated with increased risk of vertebral fractures (VFx). The effect on bone following recovery from SH is unknown. Design: Of the 605 subjects consecutively referred for monolateral adrenal incidentalomas (AIs) to our outpatient clinics, 55 SH patients (recruited on the basis of the exclusion criteria) were enrolled. We suggested to all patients to undergo adrenalectomy, which was accepted by 32 patients (surgical group, age 61.3±8.1 years) and refused by 23 patients, who were followed with a conservative management (non-surgical group, age 65.4±7.1 years). Methods:We diagnosed SH in patients with serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST)O5.0 mg/dl or with greater than or equal to two criteria among 1 mg-DST >3.0 μg/dl, urinary free cortisol >70 μg/24 h and ACTH

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