Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy

Preliminary results

Natalia Pezzali, Antonio Curnis, Claudia Specchia, Valentina Carubelli, Loredana Covolo, Francesco Donato, Angelo Auricchio, François Regoli, Marco Metra

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

AimsSeveral factors can influence the extent of left ventricular (LV) reverse remodelling after cardiac resynchronization therapy (CRT) in patients with heart failure (HF). Polymorphism in genes involved in cardiac remodelling, namely beta-adrenergic receptors (ARs), may have a role. We studied the influence of beta-1 Arg389Gly, beta-2 Arg16Gly, and beta-2 Gln27Glu ARs gene polymorphisms on the magnitude of reverse remodelling response to CRT and its possible correlations with the incidence of appropriate implantable cardioverter-defibrillator (ICD) shocks.Methods and resultsBeta-ARs were assessed in 101 patients with HF due to idiopathic (50.5%) or ischaemic (49.5%) dilated cardiomyopathy, undergoing CRT for standard indications [left ventricular ejection fraction (LVEF) 23.5 ± 7.5%, QRS ≥ 120 ms]. Left ventricular ejection fraction was measured by echocardiography at baseline, 6 months after CRT, and periodically afterwards. The LVEF change from baseline was of 3.1 ± 11 units among Gln27Gln, 8.3 ± 10.4 units among Gln27Glu, 11 ± 6.4 units among Glu27Glu carriers (P = 0.018 for Gln27Gln vs. Glu27Glu carriers), and 8.8 ± 9.8 units among Gln27Glu + Glu27Glu carriers (P = 0.006 vs. Gln27Gln). Gln27 homozygotes had a higher incidence of appropriate ICD shocks for fast ventricular tachycardia/ventricular fibrillation.ConclusionBeta-2 Gln27Glu ARs gene polymorphism may influence LV reverse remodelling after CRT with Glu27Glu carriers showing the greatest improvement. It may also influence the incidence of malignant ventricular tachyarrhythmias.

Original languageEnglish
Pages (from-to)1475-1481
Number of pages7
JournalEuropace
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Cardiac Resynchronization Therapy
Ventricular Remodeling
Adrenergic Receptors
Stroke Volume
Implantable Defibrillators
Genes
Shock
Incidence
Heart Failure
Adrenergic beta-2 Receptors
Receptors, Adrenergic, beta
Homozygote
Dilated Cardiomyopathy
Ventricular Fibrillation
Ventricular Tachycardia
Tachycardia
Echocardiography

Keywords

  • Beta-adrenergic receptors gene polymorphism
  • Cardiac resynchronization therapy (CRT)
  • ICD shocks
  • Left ventricular reverse remodelling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy : Preliminary results. / Pezzali, Natalia; Curnis, Antonio; Specchia, Claudia; Carubelli, Valentina; Covolo, Loredana; Donato, Francesco; Auricchio, Angelo; Regoli, François; Metra, Marco.

In: Europace, Vol. 15, No. 10, 10.2013, p. 1475-1481.

Research output: Contribution to journalArticle

Pezzali, N, Curnis, A, Specchia, C, Carubelli, V, Covolo, L, Donato, F, Auricchio, A, Regoli, F & Metra, M 2013, 'Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy: Preliminary results', Europace, vol. 15, no. 10, pp. 1475-1481. https://doi.org/10.1093/europace/eut136
Pezzali, Natalia ; Curnis, Antonio ; Specchia, Claudia ; Carubelli, Valentina ; Covolo, Loredana ; Donato, Francesco ; Auricchio, Angelo ; Regoli, François ; Metra, Marco. / Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy : Preliminary results. In: Europace. 2013 ; Vol. 15, No. 10. pp. 1475-1481.
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T1 - Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy

T2 - Preliminary results

AU - Pezzali, Natalia

AU - Curnis, Antonio

AU - Specchia, Claudia

AU - Carubelli, Valentina

AU - Covolo, Loredana

AU - Donato, Francesco

AU - Auricchio, Angelo

AU - Regoli, François

AU - Metra, Marco

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N2 - AimsSeveral factors can influence the extent of left ventricular (LV) reverse remodelling after cardiac resynchronization therapy (CRT) in patients with heart failure (HF). Polymorphism in genes involved in cardiac remodelling, namely beta-adrenergic receptors (ARs), may have a role. We studied the influence of beta-1 Arg389Gly, beta-2 Arg16Gly, and beta-2 Gln27Glu ARs gene polymorphisms on the magnitude of reverse remodelling response to CRT and its possible correlations with the incidence of appropriate implantable cardioverter-defibrillator (ICD) shocks.Methods and resultsBeta-ARs were assessed in 101 patients with HF due to idiopathic (50.5%) or ischaemic (49.5%) dilated cardiomyopathy, undergoing CRT for standard indications [left ventricular ejection fraction (LVEF) 23.5 ± 7.5%, QRS ≥ 120 ms]. Left ventricular ejection fraction was measured by echocardiography at baseline, 6 months after CRT, and periodically afterwards. The LVEF change from baseline was of 3.1 ± 11 units among Gln27Gln, 8.3 ± 10.4 units among Gln27Glu, 11 ± 6.4 units among Glu27Glu carriers (P = 0.018 for Gln27Gln vs. Glu27Glu carriers), and 8.8 ± 9.8 units among Gln27Glu + Glu27Glu carriers (P = 0.006 vs. Gln27Gln). Gln27 homozygotes had a higher incidence of appropriate ICD shocks for fast ventricular tachycardia/ventricular fibrillation.ConclusionBeta-2 Gln27Glu ARs gene polymorphism may influence LV reverse remodelling after CRT with Glu27Glu carriers showing the greatest improvement. It may also influence the incidence of malignant ventricular tachyarrhythmias.

AB - AimsSeveral factors can influence the extent of left ventricular (LV) reverse remodelling after cardiac resynchronization therapy (CRT) in patients with heart failure (HF). Polymorphism in genes involved in cardiac remodelling, namely beta-adrenergic receptors (ARs), may have a role. We studied the influence of beta-1 Arg389Gly, beta-2 Arg16Gly, and beta-2 Gln27Glu ARs gene polymorphisms on the magnitude of reverse remodelling response to CRT and its possible correlations with the incidence of appropriate implantable cardioverter-defibrillator (ICD) shocks.Methods and resultsBeta-ARs were assessed in 101 patients with HF due to idiopathic (50.5%) or ischaemic (49.5%) dilated cardiomyopathy, undergoing CRT for standard indications [left ventricular ejection fraction (LVEF) 23.5 ± 7.5%, QRS ≥ 120 ms]. Left ventricular ejection fraction was measured by echocardiography at baseline, 6 months after CRT, and periodically afterwards. The LVEF change from baseline was of 3.1 ± 11 units among Gln27Gln, 8.3 ± 10.4 units among Gln27Glu, 11 ± 6.4 units among Glu27Glu carriers (P = 0.018 for Gln27Gln vs. Glu27Glu carriers), and 8.8 ± 9.8 units among Gln27Glu + Glu27Glu carriers (P = 0.006 vs. Gln27Gln). Gln27 homozygotes had a higher incidence of appropriate ICD shocks for fast ventricular tachycardia/ventricular fibrillation.ConclusionBeta-2 Gln27Glu ARs gene polymorphism may influence LV reverse remodelling after CRT with Glu27Glu carriers showing the greatest improvement. It may also influence the incidence of malignant ventricular tachyarrhythmias.

KW - Beta-adrenergic receptors gene polymorphism

KW - Cardiac resynchronization therapy (CRT)

KW - ICD shocks

KW - Left ventricular reverse remodelling

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