Adrenocortical tumors: The experience of the "Bambino Gesù" Research Institute in Rome

A. Inserra, S. Madafferi, R. Devito, A. Donfrancesco, C. Boglino

Research output: Contribution to journalArticlepeer-review


Aims. Adrenocortical tumors (ACT) are rare in childhood. The low incidence of this pathology, the need for early surgical treatment and the lack of a really active chemotherapy has prompted us to analyse our cases. Patients and methods. We report three cases of adrenocortical tumors treated at the Bambino Gesù Children Hospital between 1996 and 2004. Diagnosis was made on the basis of symptoms, hormonal tests and radiological findings. Results. All patients had androgen secretion and virilising syndrome. At the ultrasound scan and total body CT there were two masses on the left side and one on the right. One patient presented also with bilateral pulmonary and bone metastases. All patients underwent total excision of the original mass, followed by Mitotane® therapy and, in two cases, chemotherapy as well. At follow-up two patients were free of disease after a median period of 70 months since diagnosis. One patient died for disease progression. Discussion. ACT are treated with total excision, without complications in almost cases. The most important aspect of therapy is early diagnosis, which is difficult in puberty, especially in males. There are currently no suitable protocols for children. Follow-up is important to identify early recurrence and prevent negative prognosis.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalItalian Journal of Pediatrics
Issue number5
Publication statusPublished - Oct 2005


  • Adenoma
  • Adrenal glands
  • Carcinoma
  • Childhood

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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