Adriamycin in hyperthermic perfusion for advanced limb sarcomas

C. R. Rossi, A. Vecchiato, P. P. Da Pian, D. Nitti, M. Lise, P. L. Melanotte, S. Turra, F. Vigliani

Research output: Contribution to journalArticlepeer-review


From February 1989 to April 1991, 12 hyperthermic limb perfusions (HLP) with adriamycin (ADR) were performed in 12 patients with high grade soft tissue sarcomas (9 in the leg and 3 in the arm); two were at A.J.C. stage IIb, eight stage IIIb and two stage IV. ADR (0.7-1.5 mg/kg) was administered in bolus at a mean temperature of 41.5°C and perfused for 60 min. No systemic toxicity was reported; seven patients had grade II locoregional toxicity, another four grade III and one grade IV. Tumor necrosis(radiological evaluation) was 75% in three. Limb sparing surgery was feasible in ten patients. At present eight patients are alive; three had local recurrence and four distant metastases.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalAnnals of Oncology
Issue numberSUPPL. 2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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