Adsorption of cationic antibacterial on collagen-coated titanium implant devices

M. Morra, C. Cassinelli, G. Cascardo, A. Carpi, M. Fini, G. Giavaresi, R. Giardino

Research output: Contribution to journalArticlepeer-review


Two different cationic antimicrobial molecules, chlorhexidine (CH) and poly(hexamethylenebiguanide) (PH), were adsorbed from aqueous solution to titanium implant devices surface-modified by the covalent coupling of collagen on a polyanionic acrylic acid overlayer. Results show that more antimicrobial was adsorbed on surface modified implants as compared to control titanium devices. Moreover, the kinetic of release was affected by the interaction between the polyanionic overlayer and the cationic antimicrobial, leading to slower kinetic of release in the case of CH and stable adsorption in the case of polycationic PH. These data indicate that biochemically modified collagen coated surfaces could be endowed also by antimicrobial properties, in the spirit of present researches on multifunctional implant surfaces.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalBiomedicine and Pharmacotherapy
Issue number8 SPEC. ISS.
Publication statusPublished - Oct 2004


  • Chlorhexidine
  • Collagen
  • Dental implant
  • Orthopedic implant
  • Surface modification
  • Titanium

ASJC Scopus subject areas

  • Pharmacology


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