Adult brain low-grade astrocytomas: Survival after surgery and radiotherapy

V. M. Arienti, A. Botturi, A. Boiardi, G. Broggi, M. Collice, L. Fariselli, D. Zanni, M. Botturi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In order to identify prognostic factors of survival, twelve elements of disease and treatment have been evaluated for a population of 49 patients with diffuse low-grade astrocytoma treated with surgical resection and radiotherapy. The survival values were inversely correlated with age and major residual portion. On the other hand, KPS, lobar site, grade II Daumas-Duport lesions, protoplasmatic variant, early epilepsy, hyperfractionated radiotherapy and extent of exeresis were prognostic factors correlated with survival. Tumor extent and radiation total dose were not correlated in a meaningful way. Only KPS was statistically significant when compared to all the prognostic factors. We believe that patient selection according to age, lesion site and histological features are not sufficient to generate a homogeneous tumoral population. The most appropriate therapy for treating low-grade astrocytomas is still an open subject. However, recent studies have shown that the prognostic value of a group of factors is useful to plan controlled studies that compare differentiated treatment protocols.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalNeurological Sciences
Volume22
Issue number3
DOIs
Publication statusPublished - 2001

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Astrocytoma
Radiotherapy
Survival
Brain
Clinical Protocols
Patient Selection
Population
Epilepsy
Radiation
Therapeutics
Neoplasms

Keywords

  • Diffuse low-grade astrocytoma
  • Prognostic factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Adult brain low-grade astrocytomas : Survival after surgery and radiotherapy. / Arienti, V. M.; Botturi, A.; Boiardi, A.; Broggi, G.; Collice, M.; Fariselli, L.; Zanni, D.; Botturi, M.

In: Neurological Sciences, Vol. 22, No. 3, 2001, p. 233-238.

Research output: Contribution to journalArticle

Arienti, VM, Botturi, A, Boiardi, A, Broggi, G, Collice, M, Fariselli, L, Zanni, D & Botturi, M 2001, 'Adult brain low-grade astrocytomas: Survival after surgery and radiotherapy', Neurological Sciences, vol. 22, no. 3, pp. 233-238. https://doi.org/10.1007/s100720100003
Arienti, V. M. ; Botturi, A. ; Boiardi, A. ; Broggi, G. ; Collice, M. ; Fariselli, L. ; Zanni, D. ; Botturi, M. / Adult brain low-grade astrocytomas : Survival after surgery and radiotherapy. In: Neurological Sciences. 2001 ; Vol. 22, No. 3. pp. 233-238.
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