Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium

E. Leoncini, W. Ricciardi, G. Cadoni, D. Arzani, L. Petrelli, G. Paludetti, P. Brennan, D. Luce, I. Stucker, K. Matsuo, R. Talamini, C. La Vecchia, A. F. Olshan, D. M. Winn, R. Herrero, S. Franceschi, X. Castellsague, J. Muscat, H. Morgenstern, Z. F. ZhangF. Levi, L. Dal Maso, K. Kelsey, M. McClean, T. L. Vaughan, P. Lazarus, M. P. Purdue, R. B. Hayes, C. Chen, S. M. Schwartz, O. Shangina, S. Koifman, W. Ahrens, E. Matos, P. Lagiou, J. Lissowska, N. Szeszenia-Dabrowska, L. Fernandez, A. Menezes, A. Agudo, A. W. Daudt, L. Richiardi, K. Kjaerheim, D. Mates, J. Betka, G. P. Yu, S. Schantz, L. Simonato, H. Brenner, D. I. Conway, T. V. Macfarlane, P. Thomson, E. Fabianova, A. Znaor, P. Rudnai, C. Healy, P. Boffetta, S. C. Chuang, Y. C. Lee, M. Hashibe, S. Boccia

Research output: Contribution to journalArticle

Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91; 95% CI 5 0.86-0.95 for men; adjusted OR = 0.86; 95% CI 5 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Original languageEnglish
Pages (from-to)1391
Number of pages1
JournalHead and Neck
Volume36
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Head and Neck Neoplasms
Odds Ratio
Confidence Intervals
Smoking
Mouth Neoplasms
Tobacco Use
Pharynx
Energy Intake
Alcohol Drinking
Case-Control Studies
Epidemiologic Studies
Epidemiology
Incidence
Neoplasms

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Leoncini, E., Ricciardi, W., Cadoni, G., Arzani, D., Petrelli, L., Paludetti, G., ... Boccia, S. (2014). Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium. Head and Neck, 36(10), 1391. https://doi.org/10.1002/HED

Adult height and head and neck cancer : A pooled analysis within the INHANCE Consortium. / Leoncini, E.; Ricciardi, W.; Cadoni, G.; Arzani, D.; Petrelli, L.; Paludetti, G.; Brennan, P.; Luce, D.; Stucker, I.; Matsuo, K.; Talamini, R.; La Vecchia, C.; Olshan, A. F.; Winn, D. M.; Herrero, R.; Franceschi, S.; Castellsague, X.; Muscat, J.; Morgenstern, H.; Zhang, Z. F.; Levi, F.; Dal Maso, L.; Kelsey, K.; McClean, M.; Vaughan, T. L.; Lazarus, P.; Purdue, M. P.; Hayes, R. B.; Chen, C.; Schwartz, S. M.; Shangina, O.; Koifman, S.; Ahrens, W.; Matos, E.; Lagiou, P.; Lissowska, J.; Szeszenia-Dabrowska, N.; Fernandez, L.; Menezes, A.; Agudo, A.; Daudt, A. W.; Richiardi, L.; Kjaerheim, K.; Mates, D.; Betka, J.; Yu, G. P.; Schantz, S.; Simonato, L.; Brenner, H.; Conway, D. I.; Macfarlane, T. V.; Thomson, P.; Fabianova, E.; Znaor, A.; Rudnai, P.; Healy, C.; Boffetta, P.; Chuang, S. C.; Lee, Y. C.; Hashibe, M.; Boccia, S.

In: Head and Neck, Vol. 36, No. 10, 2014, p. 1391.

Research output: Contribution to journalArticle

Leoncini, E, Ricciardi, W, Cadoni, G, Arzani, D, Petrelli, L, Paludetti, G, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, AF, Winn, DM, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, ZF, Levi, F, Dal Maso, L, Kelsey, K, McClean, M, Vaughan, TL, Lazarus, P, Purdue, MP, Hayes, RB, Chen, C, Schwartz, SM, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia-Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, AW, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, GP, Schantz, S, Simonato, L, Brenner, H, Conway, DI, Macfarlane, TV, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, SC, Lee, YC, Hashibe, M & Boccia, S 2014, 'Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium', Head and Neck, vol. 36, no. 10, pp. 1391. https://doi.org/10.1002/HED
Leoncini E, Ricciardi W, Cadoni G, Arzani D, Petrelli L, Paludetti G et al. Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium. Head and Neck. 2014;36(10):1391. https://doi.org/10.1002/HED
Leoncini, E. ; Ricciardi, W. ; Cadoni, G. ; Arzani, D. ; Petrelli, L. ; Paludetti, G. ; Brennan, P. ; Luce, D. ; Stucker, I. ; Matsuo, K. ; Talamini, R. ; La Vecchia, C. ; Olshan, A. F. ; Winn, D. M. ; Herrero, R. ; Franceschi, S. ; Castellsague, X. ; Muscat, J. ; Morgenstern, H. ; Zhang, Z. F. ; Levi, F. ; Dal Maso, L. ; Kelsey, K. ; McClean, M. ; Vaughan, T. L. ; Lazarus, P. ; Purdue, M. P. ; Hayes, R. B. ; Chen, C. ; Schwartz, S. M. ; Shangina, O. ; Koifman, S. ; Ahrens, W. ; Matos, E. ; Lagiou, P. ; Lissowska, J. ; Szeszenia-Dabrowska, N. ; Fernandez, L. ; Menezes, A. ; Agudo, A. ; Daudt, A. W. ; Richiardi, L. ; Kjaerheim, K. ; Mates, D. ; Betka, J. ; Yu, G. P. ; Schantz, S. ; Simonato, L. ; Brenner, H. ; Conway, D. I. ; Macfarlane, T. V. ; Thomson, P. ; Fabianova, E. ; Znaor, A. ; Rudnai, P. ; Healy, C. ; Boffetta, P. ; Chuang, S. C. ; Lee, Y. C. ; Hashibe, M. ; Boccia, S. / Adult height and head and neck cancer : A pooled analysis within the INHANCE Consortium. In: Head and Neck. 2014 ; Vol. 36, No. 10. pp. 1391.
@article{111f789111b14dd2a6d660af637534f1,
title = "Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium",
abstract = "Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91; 95{\%} CI 5 0.86-0.95 for men; adjusted OR = 0.86; 95{\%} CI 5 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.",
author = "E. Leoncini and W. Ricciardi and G. Cadoni and D. Arzani and L. Petrelli and G. Paludetti and P. Brennan and D. Luce and I. Stucker and K. Matsuo and R. Talamini and {La Vecchia}, C. and Olshan, {A. F.} and Winn, {D. M.} and R. Herrero and S. Franceschi and X. Castellsague and J. Muscat and H. Morgenstern and Zhang, {Z. F.} and F. Levi and {Dal Maso}, L. and K. Kelsey and M. McClean and Vaughan, {T. L.} and P. Lazarus and Purdue, {M. P.} and Hayes, {R. B.} and C. Chen and Schwartz, {S. M.} and O. Shangina and S. Koifman and W. Ahrens and E. Matos and P. Lagiou and J. Lissowska and N. Szeszenia-Dabrowska and L. Fernandez and A. Menezes and A. Agudo and Daudt, {A. W.} and L. Richiardi and K. Kjaerheim and D. Mates and J. Betka and Yu, {G. P.} and S. Schantz and L. Simonato and H. Brenner and Conway, {D. I.} and Macfarlane, {T. V.} and P. Thomson and E. Fabianova and A. Znaor and P. Rudnai and C. Healy and P. Boffetta and Chuang, {S. C.} and Lee, {Y. C.} and M. Hashibe and S. Boccia",
year = "2014",
doi = "10.1002/HED",
language = "English",
volume = "36",
pages = "1391",
journal = "Head and Neck Surgery",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "10",

}

TY - JOUR

T1 - Adult height and head and neck cancer

T2 - A pooled analysis within the INHANCE Consortium

AU - Leoncini, E.

AU - Ricciardi, W.

AU - Cadoni, G.

AU - Arzani, D.

AU - Petrelli, L.

AU - Paludetti, G.

AU - Brennan, P.

AU - Luce, D.

AU - Stucker, I.

AU - Matsuo, K.

AU - Talamini, R.

AU - La Vecchia, C.

AU - Olshan, A. F.

AU - Winn, D. M.

AU - Herrero, R.

AU - Franceschi, S.

AU - Castellsague, X.

AU - Muscat, J.

AU - Morgenstern, H.

AU - Zhang, Z. F.

AU - Levi, F.

AU - Dal Maso, L.

AU - Kelsey, K.

AU - McClean, M.

AU - Vaughan, T. L.

AU - Lazarus, P.

AU - Purdue, M. P.

AU - Hayes, R. B.

AU - Chen, C.

AU - Schwartz, S. M.

AU - Shangina, O.

AU - Koifman, S.

AU - Ahrens, W.

AU - Matos, E.

AU - Lagiou, P.

AU - Lissowska, J.

AU - Szeszenia-Dabrowska, N.

AU - Fernandez, L.

AU - Menezes, A.

AU - Agudo, A.

AU - Daudt, A. W.

AU - Richiardi, L.

AU - Kjaerheim, K.

AU - Mates, D.

AU - Betka, J.

AU - Yu, G. P.

AU - Schantz, S.

AU - Simonato, L.

AU - Brenner, H.

AU - Conway, D. I.

AU - Macfarlane, T. V.

AU - Thomson, P.

AU - Fabianova, E.

AU - Znaor, A.

AU - Rudnai, P.

AU - Healy, C.

AU - Boffetta, P.

AU - Chuang, S. C.

AU - Lee, Y. C.

AU - Hashibe, M.

AU - Boccia, S.

PY - 2014

Y1 - 2014

N2 - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91; 95% CI 5 0.86-0.95 for men; adjusted OR = 0.86; 95% CI 5 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

AB - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91; 95% CI 5 0.86-0.95 for men; adjusted OR = 0.86; 95% CI 5 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

UR - http://www.scopus.com/inward/record.url?scp=84908050214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908050214&partnerID=8YFLogxK

U2 - 10.1002/HED

DO - 10.1002/HED

M3 - Article

AN - SCOPUS:84908050214

VL - 36

SP - 1391

JO - Head and Neck Surgery

JF - Head and Neck Surgery

SN - 1043-3074

IS - 10

ER -