TY - JOUR
T1 - Adult osteomyelitis
T2 - Debridement versus debridement plus Osteoset T® pellets
AU - Chang, Wang
AU - Colangeli, Marco
AU - Colangeli, Simone
AU - Di Bella, Claudia
AU - Gozzi, Enrico
AU - Donati, Davide
PY - 2007/4
Y1 - 2007/4
N2 - This long-term retrospective study investigated the value of debridement versus debridement and Osteoset T® antibiotic-loaded calcium sulphate pellets in the treatment of adult chronic osteomyelitis. Sixty-five patients were included in the study. The mean follow-up was 75 months (range : 36 to 334). Forty cases were treated by debridement, and 25 by debridement and Osteoset T®. The healing rates were 60% and 80%, respectively; however, the difference was not significant. In a subgroup of 39 patients with medullary osteomyelitis and a normal immune system (IA according to the Cierny-Mader classification of adult osteomyelitis), 22 patients were treated with debridement, 17 with debridement and Osteoset T®. The healing rates were 59% and 94%, respectively (p <0.05). Twenty-eight patients with Staphylococcus aureus osteomyelitis were also studied apart; 13 were treated with debridement and 15 with debridement and Osteoset T. The healing rates were 46% and 80%, respectively. The difference was not significant. The results obtained with debridement were less good than with debridement plus Osteoset T®, but the difference was not significant, except in a single subgroup. Osteoset T® obviates the need for removal, which is the rule after implantation of gentamycin beads. Bony ingrowth is however limited.
AB - This long-term retrospective study investigated the value of debridement versus debridement and Osteoset T® antibiotic-loaded calcium sulphate pellets in the treatment of adult chronic osteomyelitis. Sixty-five patients were included in the study. The mean follow-up was 75 months (range : 36 to 334). Forty cases were treated by debridement, and 25 by debridement and Osteoset T®. The healing rates were 60% and 80%, respectively; however, the difference was not significant. In a subgroup of 39 patients with medullary osteomyelitis and a normal immune system (IA according to the Cierny-Mader classification of adult osteomyelitis), 22 patients were treated with debridement, 17 with debridement and Osteoset T®. The healing rates were 59% and 94%, respectively (p <0.05). Twenty-eight patients with Staphylococcus aureus osteomyelitis were also studied apart; 13 were treated with debridement and 15 with debridement and Osteoset T. The healing rates were 46% and 80%, respectively. The difference was not significant. The results obtained with debridement were less good than with debridement plus Osteoset T®, but the difference was not significant, except in a single subgroup. Osteoset T® obviates the need for removal, which is the rule after implantation of gentamycin beads. Bony ingrowth is however limited.
KW - Bone substitute
KW - Clinical study
KW - Local antibiotic delivery
KW - Osteomyelitis
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UR - http://www.scopus.com/inward/citedby.url?scp=34248155695&partnerID=8YFLogxK
M3 - Article
C2 - 17515238
AN - SCOPUS:34248155695
VL - 73
SP - 238
EP - 244
JO - Acta Orthopaedica Belgica
JF - Acta Orthopaedica Belgica
SN - 0001-6462
IS - 2
ER -