Adult stem cells and the clinical arena: Are we able to widely use this therapy in patients with chronic limbs arteriopathy and ischemic ulcers without possibility of revascularization?

Amelia Casamassimi, Vincenzo Grimaldi, Teresa Infante, Mohammed Al-Omran, Valeria Crudele, Claudio Napoli

Research output: Contribution to journalArticle

Abstract

The following paper is an overview on stem cells therapy in patients with peripheral vascular diseases. Recent research shows the ability of stem cells to develop and strengthen the collateral network in ischemic legs. Here, we discuss this clinical and therapeutic approach. To date, research has been mainly focused on patients with ischemic ulcers without possibility of revascularization. Non-invasive stem cell therapy has been proposed as an alternative to the amputation of such patients, but when the ulcers appear it is sometime too late. In our point of view, the selection of patients is a very important issue and we believe that the best candidate for this treatment is the patient with intermittent claudication before the development of ulcers. This choice could allow the optimization of results by the type of treated patients and not only by the type of infused cells. Indeed, several variables still remain to be elucidated for stem cell therapy, including the type of cells to be used, the infusion route, and more importantly, the stage of patients to be treated.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalCardiovascular and Hematological Agents in Medicinal Chemistry
Volume10
Issue number2
Publication statusPublished - Jun 2012

Keywords

  • Angiogenesis
  • Autologous transplantation
  • Bone marrow cells
  • Circulating endothelial progenitor cells
  • Clinical trials
  • Fontaine's stage
  • Gangrene
  • Intermittent claudication
  • Limb ischemia
  • Peripheral arterial disease
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology
  • Pharmacology

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