Adult syncytial giant cell chronic hepatitis due to herbal remedy

Mirella Fraquelli, Agostino Colli, Massimo Cocciolo, Dario Conte

Research output: Contribution to journalArticle

Abstract

Syncytial giant cell hepatitis is an uncommon form of chronic hepatitis in adults, although it has been reported in association with viral infection (including HCV and HIV infection), drug reactions and autoimmune disorders. We here report a very unusual ease of giant cell chronic hepatitis in a 26-old-woman, who had been taking a herbal remedy (ISABGOL) for chronic constipation. The presence of viral and metabolic diseases has been excluded; an autoimmune etiology was very unlikely as the autoimmunity test remained negative during the year of follow-up and the total disease score normalized (from 13 to 8) without corticosteroid treatment. The causative role of the herbal remedy was further supported by the spontaneous and dramatic clinical, biochemical and histologic improvement observed following its withdrawal, despite the absence of any treatment.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalJournal of Hepatology
Volume33
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Virus Diseases
Giant Cells
Chronic Hepatitis
Metabolic Diseases
Constipation
Autoimmunity
Hepatitis
HIV Infections
Adrenal Cortex Hormones
Therapeutics
Pharmaceutical Preparations

Keywords

  • Herbal remedy
  • Syncytial giant cell hepatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Adult syncytial giant cell chronic hepatitis due to herbal remedy. / Fraquelli, Mirella; Colli, Agostino; Cocciolo, Massimo; Conte, Dario.

In: Journal of Hepatology, Vol. 33, No. 3, 2000, p. 505-508.

Research output: Contribution to journalArticle

Fraquelli, Mirella ; Colli, Agostino ; Cocciolo, Massimo ; Conte, Dario. / Adult syncytial giant cell chronic hepatitis due to herbal remedy. In: Journal of Hepatology. 2000 ; Vol. 33, No. 3. pp. 505-508.
@article{89f213c406d74d488a2ba5ca02d6e2ba,
title = "Adult syncytial giant cell chronic hepatitis due to herbal remedy",
abstract = "Syncytial giant cell hepatitis is an uncommon form of chronic hepatitis in adults, although it has been reported in association with viral infection (including HCV and HIV infection), drug reactions and autoimmune disorders. We here report a very unusual ease of giant cell chronic hepatitis in a 26-old-woman, who had been taking a herbal remedy (ISABGOL) for chronic constipation. The presence of viral and metabolic diseases has been excluded; an autoimmune etiology was very unlikely as the autoimmunity test remained negative during the year of follow-up and the total disease score normalized (from 13 to 8) without corticosteroid treatment. The causative role of the herbal remedy was further supported by the spontaneous and dramatic clinical, biochemical and histologic improvement observed following its withdrawal, despite the absence of any treatment.",
keywords = "Herbal remedy, Syncytial giant cell hepatitis",
author = "Mirella Fraquelli and Agostino Colli and Massimo Cocciolo and Dario Conte",
year = "2000",
doi = "10.1016/S0168-8278(00)80289-5",
language = "English",
volume = "33",
pages = "505--508",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier B.V.",
number = "3",

}

TY - JOUR

T1 - Adult syncytial giant cell chronic hepatitis due to herbal remedy

AU - Fraquelli, Mirella

AU - Colli, Agostino

AU - Cocciolo, Massimo

AU - Conte, Dario

PY - 2000

Y1 - 2000

N2 - Syncytial giant cell hepatitis is an uncommon form of chronic hepatitis in adults, although it has been reported in association with viral infection (including HCV and HIV infection), drug reactions and autoimmune disorders. We here report a very unusual ease of giant cell chronic hepatitis in a 26-old-woman, who had been taking a herbal remedy (ISABGOL) for chronic constipation. The presence of viral and metabolic diseases has been excluded; an autoimmune etiology was very unlikely as the autoimmunity test remained negative during the year of follow-up and the total disease score normalized (from 13 to 8) without corticosteroid treatment. The causative role of the herbal remedy was further supported by the spontaneous and dramatic clinical, biochemical and histologic improvement observed following its withdrawal, despite the absence of any treatment.

AB - Syncytial giant cell hepatitis is an uncommon form of chronic hepatitis in adults, although it has been reported in association with viral infection (including HCV and HIV infection), drug reactions and autoimmune disorders. We here report a very unusual ease of giant cell chronic hepatitis in a 26-old-woman, who had been taking a herbal remedy (ISABGOL) for chronic constipation. The presence of viral and metabolic diseases has been excluded; an autoimmune etiology was very unlikely as the autoimmunity test remained negative during the year of follow-up and the total disease score normalized (from 13 to 8) without corticosteroid treatment. The causative role of the herbal remedy was further supported by the spontaneous and dramatic clinical, biochemical and histologic improvement observed following its withdrawal, despite the absence of any treatment.

KW - Herbal remedy

KW - Syncytial giant cell hepatitis

UR - http://www.scopus.com/inward/record.url?scp=0033845826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033845826&partnerID=8YFLogxK

U2 - 10.1016/S0168-8278(00)80289-5

DO - 10.1016/S0168-8278(00)80289-5

M3 - Article

C2 - 11020009

AN - SCOPUS:0033845826

VL - 33

SP - 505

EP - 508

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 3

ER -