Abstract
Introduction: This report reflects a retrospective comparison among historical series of patients with similar site and stage of disease treated by three fractionation schemes. Materlals and Methods. A hyperfractionation (HF) scheme delivered 1 Gy three times a day, 5 days a week, to a total dose of 60 to 63 Gy over 26 to 29 days. A group of 48 patients received HF. Accelerated fractionation (AF) consists of 2 Gy three times a day, 5 days a week, to a total of 48 to 52 Gy delivered over 11 to 12 days. A group of 46 patients underwent this therapy. A third group of 48 patients were treated with conventional fractionation (CF). These patients received 2 Gy each day, 5 days a week, to a total dose of 60 to 66 Gy. Results: Ned survival at 5 years was 23.8%, 32.8%, and 29.3% for CF, AF, and HF, respectively. The most important cause of failure was inability to control disease at the primary site; however, isolated distant metastasis were observed in 15.4% of all failures. Treatment delays were more common in the HF and CF groups. The highest incidence of late complications occurred in the AF group. Conclusions: Advanced lesions of the oropharynx have an ominous prognosis. New fractionation regimens represent a warranted approach as an alternative to or an integration into combined chemotherapy and radiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 31-37 |
| Number of pages | 7 |
| Journal | American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Otorhinolaryngology
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Advanced carcinomas of the oropharynx treated with radiotherapy-A comparison of three different fractionation schemes. / Fallai, Carlo; Olmi, Patrizia; Cellai, Enrico.
In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 14, No. 1, 1993, p. 31-37.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Advanced carcinomas of the oropharynx treated with radiotherapy-A comparison of three different fractionation schemes
AU - Fallai, Carlo
AU - Olmi, Patrizia
AU - Cellai, Enrico
PY - 1993
Y1 - 1993
N2 - Introduction: This report reflects a retrospective comparison among historical series of patients with similar site and stage of disease treated by three fractionation schemes. Materlals and Methods. A hyperfractionation (HF) scheme delivered 1 Gy three times a day, 5 days a week, to a total dose of 60 to 63 Gy over 26 to 29 days. A group of 48 patients received HF. Accelerated fractionation (AF) consists of 2 Gy three times a day, 5 days a week, to a total of 48 to 52 Gy delivered over 11 to 12 days. A group of 46 patients underwent this therapy. A third group of 48 patients were treated with conventional fractionation (CF). These patients received 2 Gy each day, 5 days a week, to a total dose of 60 to 66 Gy. Results: Ned survival at 5 years was 23.8%, 32.8%, and 29.3% for CF, AF, and HF, respectively. The most important cause of failure was inability to control disease at the primary site; however, isolated distant metastasis were observed in 15.4% of all failures. Treatment delays were more common in the HF and CF groups. The highest incidence of late complications occurred in the AF group. Conclusions: Advanced lesions of the oropharynx have an ominous prognosis. New fractionation regimens represent a warranted approach as an alternative to or an integration into combined chemotherapy and radiotherapy.
AB - Introduction: This report reflects a retrospective comparison among historical series of patients with similar site and stage of disease treated by three fractionation schemes. Materlals and Methods. A hyperfractionation (HF) scheme delivered 1 Gy three times a day, 5 days a week, to a total dose of 60 to 63 Gy over 26 to 29 days. A group of 48 patients received HF. Accelerated fractionation (AF) consists of 2 Gy three times a day, 5 days a week, to a total of 48 to 52 Gy delivered over 11 to 12 days. A group of 46 patients underwent this therapy. A third group of 48 patients were treated with conventional fractionation (CF). These patients received 2 Gy each day, 5 days a week, to a total dose of 60 to 66 Gy. Results: Ned survival at 5 years was 23.8%, 32.8%, and 29.3% for CF, AF, and HF, respectively. The most important cause of failure was inability to control disease at the primary site; however, isolated distant metastasis were observed in 15.4% of all failures. Treatment delays were more common in the HF and CF groups. The highest incidence of late complications occurred in the AF group. Conclusions: Advanced lesions of the oropharynx have an ominous prognosis. New fractionation regimens represent a warranted approach as an alternative to or an integration into combined chemotherapy and radiotherapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027526169&partnerID=8YFLogxK
U2 - 10.1016/0196-0709(93)90007-T
DO - 10.1016/0196-0709(93)90007-T
M3 - Article
VL - 14
SP - 31
EP - 37
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
SN - 0196-0709
IS - 1
ER -