Advanced colon cancer: Staging and prognosis by CEA test

Carlo Barone, A. Astone, A. Cassano, C. Garufi, P. Astone, A. Grieco, M. R. Noviello, E. Ricevuto, C. Albanese, G. Gam Bassi

Research output: Contribution to journalArticle

Abstract

The carcinoembryonic antigen (CEA) test was studied in 54 patients with advanced stages of colon cancer which was treated with high doses of folinic acid + fiuorouracil. The CEA test correlates evaluated included: prognostic value, performance status, metastatic pattern, histologic grading, predictive value for response to chemotherapy, and value differences in cases with partial response to therapy. CEA levels <5 ng/ml corresponded to a greater survival time than did levels >5 ng/ml. A correlation of CEA with performance status and with metastatic pattern was demonstrated. A progressive increase in average CEA values corresponded to increases in neoplastic mass. Although CEA levels were not found to be an index for predicting the response to chemotherapy, there was a significant difference between pre- and posttreatment levels for partial response. The results suggest that CEA offers an additional criterion for evaluating the response of colon cancer to chemotherapy and it also has a role in the staging of advanced disease.

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalOncology
Volume47
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • Carcinoembryonic antigen
  • Colorectal cancer
  • Prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Barone, C., Astone, A., Cassano, A., Garufi, C., Astone, P., Grieco, A., Noviello, M. R., Ricevuto, E., Albanese, C., & Bassi, G. G. (1990). Advanced colon cancer: Staging and prognosis by CEA test. Oncology, 47(2), 128-132. https://doi.org/10.1159/000226804