Advanced magnetic resonance imaging of neuromyelitis optica: A multiparametric approach

A. Pichiecchio, E. Tavazzi, G. Poloni, M. Ponzio, F. Palesi, M. Pasin, L. Piccolo, D. Tosello, A. Romani, R. Bergamaschi, G. Piccolo, S. Bastianello

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: Several authors have used advanced magnetic resonance imaging (MRI) techniques to investigate whether patients with neuromyelitis optica (NMO) have occult damage in normal-appearing brain tissue, similarly to multiple sclerosis (MS). To date, the literature contains no data derived from the combined use of several advanced MRI techniques in the same NMO subjects.Objective: We set out to determine whether occult damage could be detected in the normal-appearing brain tissue of a small group of patients with NMO using a multiparametric MRI approach.Methods: Eight female patients affected by NMO (age range 44-58 years) and seven sex- and age-matched healthy controls were included. The techniques used on a 1.5 T MRI imaging scanner were magnetization transfer imaging, diffusion tensor imaging, tract-based spatial statistics, spectroscopy and voxel-based morphometry in order to analyse normal-appearing white matter and normal-appearing grey matter.Results: Structural and metabolic parameters showed no abnormalities in normal-appearing white matter of patients with NMO. Conversely, tract-based spatial statistics demonstrated a selective alteration of the optic pathways and the lateral geniculate nuclei. Diffusion tensor imaging values in the normal-appearing grey matter were found to be significantly different in the patients with NMO versus the healthy controls. Moreover, voxel-based morphometry analysis demonstrated a significant density and volume reduction of the sensorimotor cortex and the visual cortex.Conclusions: Our data disclosed occult structural damage in the brain of patients with NMO, predominantly involving regions connected with motor and visual systems. This damage seems to be the direct consequence of transsynaptic degeneration triggered by lesions of the optic nerve and spine.

Original languageEnglish
Pages (from-to)817-824
Number of pages8
JournalMultiple Sclerosis Journal
Volume18
Issue number6
DOIs
Publication statusPublished - 2012

Fingerprint

Neuromyelitis Optica
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Brain
Geniculate Bodies
Visual Cortex
Optic Nerve
Multiple Sclerosis
Spectrum Analysis
Reference Values
Spine

Keywords

  • Advanced MRI techniques
  • DTI
  • neuromyelitis optica
  • spectroscopy
  • VBM

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Advanced magnetic resonance imaging of neuromyelitis optica : A multiparametric approach. / Pichiecchio, A.; Tavazzi, E.; Poloni, G.; Ponzio, M.; Palesi, F.; Pasin, M.; Piccolo, L.; Tosello, D.; Romani, A.; Bergamaschi, R.; Piccolo, G.; Bastianello, S.

In: Multiple Sclerosis Journal, Vol. 18, No. 6, 2012, p. 817-824.

Research output: Contribution to journalArticle

Pichiecchio, A, Tavazzi, E, Poloni, G, Ponzio, M, Palesi, F, Pasin, M, Piccolo, L, Tosello, D, Romani, A, Bergamaschi, R, Piccolo, G & Bastianello, S 2012, 'Advanced magnetic resonance imaging of neuromyelitis optica: A multiparametric approach', Multiple Sclerosis Journal, vol. 18, no. 6, pp. 817-824. https://doi.org/10.1177/1352458511431072
Pichiecchio, A. ; Tavazzi, E. ; Poloni, G. ; Ponzio, M. ; Palesi, F. ; Pasin, M. ; Piccolo, L. ; Tosello, D. ; Romani, A. ; Bergamaschi, R. ; Piccolo, G. ; Bastianello, S. / Advanced magnetic resonance imaging of neuromyelitis optica : A multiparametric approach. In: Multiple Sclerosis Journal. 2012 ; Vol. 18, No. 6. pp. 817-824.
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