Advanced nanocomposite materials for orthopaedic applications. I. A long-term in vitro wear study of zirconia-toughened alumina

S. Affatato, R. Torrecillas, P. Taddei, M. Rocchi, C. Fagnano, G. Ciapetti, A. Toni

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The use of ceramic-on-ceramic (alumina- and zirconia-based) couplings in hip joint prostheses has been reported to produce lower wear rates than other combinations (i.e., metal-on-polyethylene and ceramic-on-polyethylene). The addition of zirconia into an alumina matrix (zirconia-toughened alumina, ZTA) has been reported to result in an enhancement of flexural strength, fracture toughness, and fatigue resistance. The development of new processing routes in nonaqueous media has allowed to obtain high-density ZTA nanocomposites with a very homogeneous microstructure and a significantly smaller and narrower particle-size distribution of zirconia than conventional powder mixing methods. The aim of the present study was to set up and validate a new ZTA nanocomposite by testing its biocompatibility and wear behavior in a hip-joint simulator in comparison with commercial alumina and experimental alumina specimens. The primary osteoblast proliferation onto ZTA nanocomposite samples was found to be not significantly different from that onto commercial alumina samples. After 7 million cycles, no significant differences were observed between the wear behaviors of the three sets of cups. In this light, it can be affirmed that ZTA nanocomposite materials can offer the option of improving the lifetime and reliability of ceramic joint prostheses.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume78
Issue number1
DOIs
Publication statusPublished - Jul 2006

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Nanocomposites
Aluminum Oxide
Orthopedics
Zirconia
Alumina
Wear of materials
Ceramics
Joint prostheses
Joint Prosthesis
Hip Joint
Polyethylene
Polyethylenes
zirconium oxide
In Vitro Techniques
Materials Testing
Hip Prosthesis
Stress Fractures
Osteoblasts
Biocompatibility
Particle Size

Keywords

  • Biocompatibility
  • Ceramic materials
  • Hip simulator
  • Nanocomposites
  • Zirconia-toughened alumina

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Advanced nanocomposite materials for orthopaedic applications. I. A long-term in vitro wear study of zirconia-toughened alumina. / Affatato, S.; Torrecillas, R.; Taddei, P.; Rocchi, M.; Fagnano, C.; Ciapetti, G.; Toni, A.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 78, No. 1, 07.2006, p. 76-82.

Research output: Contribution to journalArticle

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