Advanced parameters of cardiac mechanics in children with CKD: The 4C study

Marcello Chinali, Maria Chiara Matteucci, Alessio Franceschini, Anke Doyon, Giacomo Pongiglione, Gabriele Rinelli, Franz Schaefer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background and objectives Newer parameters of cardiac mechanics provide additional insights on cardiac dysfunction in adult patients with CKD. The aim of this study was to identify prevalence of subclinical abnormalities in cardiac function through the analysis of novel indices of cardiac mechanics in a large population of children with CKD. Design, setting, participants, & measurements Between 2009 and 2011, the prospective observational Cardiovascular Comorbidity in Children with CKD Study enrolled patients with CKD ages 6–17 years old with eGFR=10–45 ml/min per 1.73 m2 in 14 European countries. Cardiac morphology and function were assessed through echocardiography. The analysis presented encompasses global radial, longitudinal, and circumferential strains as well as time to peak analysis. Data were compared with 61 healthy children with comparable age and sex. Results Data on 272 patients with CKD with complete echocardiographic assessment are reported (age =12.8±3.5 years old; 65% boys). Patients with CKD showed mildly higher office BP values and higher prevalence of left ventricular hypertrophy, but no differences were observed among groups in left ventricular ejection fraction. Strain analysis showed significantly lower global radial strain (29.6%±13.3% versus 35.5%±8.9%) and circumferential strain components (−21.8%±4.8% versus −28.2%±5.0%; both P

Original languageEnglish
Pages (from-to)1357-1363
Number of pages7
JournalClinical Journal of the American Society of Nephrology
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 7 2015

Fingerprint

Mechanics
Left Ventricular Hypertrophy
Stroke Volume
Echocardiography
Comorbidity
Population

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Chinali, M., Matteucci, M. C., Franceschini, A., Doyon, A., Pongiglione, G., Rinelli, G., & Schaefer, F. (2015). Advanced parameters of cardiac mechanics in children with CKD: The 4C study. Clinical Journal of the American Society of Nephrology, 10(8), 1357-1363. https://doi.org/10.2215/CJN.10921114

Advanced parameters of cardiac mechanics in children with CKD : The 4C study. / Chinali, Marcello; Matteucci, Maria Chiara; Franceschini, Alessio; Doyon, Anke; Pongiglione, Giacomo; Rinelli, Gabriele; Schaefer, Franz.

In: Clinical Journal of the American Society of Nephrology, Vol. 10, No. 8, 07.08.2015, p. 1357-1363.

Research output: Contribution to journalArticle

Chinali, M, Matteucci, MC, Franceschini, A, Doyon, A, Pongiglione, G, Rinelli, G & Schaefer, F 2015, 'Advanced parameters of cardiac mechanics in children with CKD: The 4C study', Clinical Journal of the American Society of Nephrology, vol. 10, no. 8, pp. 1357-1363. https://doi.org/10.2215/CJN.10921114
Chinali, Marcello ; Matteucci, Maria Chiara ; Franceschini, Alessio ; Doyon, Anke ; Pongiglione, Giacomo ; Rinelli, Gabriele ; Schaefer, Franz. / Advanced parameters of cardiac mechanics in children with CKD : The 4C study. In: Clinical Journal of the American Society of Nephrology. 2015 ; Vol. 10, No. 8. pp. 1357-1363.
@article{9321fb19a6bc49cebfa16e71d0b04c45,
title = "Advanced parameters of cardiac mechanics in children with CKD: The 4C study",
abstract = "Background and objectives Newer parameters of cardiac mechanics provide additional insights on cardiac dysfunction in adult patients with CKD. The aim of this study was to identify prevalence of subclinical abnormalities in cardiac function through the analysis of novel indices of cardiac mechanics in a large population of children with CKD. Design, setting, participants, & measurements Between 2009 and 2011, the prospective observational Cardiovascular Comorbidity in Children with CKD Study enrolled patients with CKD ages 6–17 years old with eGFR=10–45 ml/min per 1.73 m2 in 14 European countries. Cardiac morphology and function were assessed through echocardiography. The analysis presented encompasses global radial, longitudinal, and circumferential strains as well as time to peak analysis. Data were compared with 61 healthy children with comparable age and sex. Results Data on 272 patients with CKD with complete echocardiographic assessment are reported (age =12.8±3.5 years old; 65{\%} boys). Patients with CKD showed mildly higher office BP values and higher prevalence of left ventricular hypertrophy, but no differences were observed among groups in left ventricular ejection fraction. Strain analysis showed significantly lower global radial strain (29.6{\%}±13.3{\%} versus 35.5{\%}±8.9{\%}) and circumferential strain components (−21.8{\%}±4.8{\%} versus −28.2{\%}±5.0{\%}; both P",
author = "Marcello Chinali and Matteucci, {Maria Chiara} and Alessio Franceschini and Anke Doyon and Giacomo Pongiglione and Gabriele Rinelli and Franz Schaefer",
year = "2015",
month = "8",
day = "7",
doi = "10.2215/CJN.10921114",
language = "English",
volume = "10",
pages = "1357--1363",
journal = "Clinical journal of the American Society of Nephrology : CJASN",
issn = "1555-9041",
publisher = "by the American Society of Nephrology",
number = "8",

}

TY - JOUR

T1 - Advanced parameters of cardiac mechanics in children with CKD

T2 - The 4C study

AU - Chinali, Marcello

AU - Matteucci, Maria Chiara

AU - Franceschini, Alessio

AU - Doyon, Anke

AU - Pongiglione, Giacomo

AU - Rinelli, Gabriele

AU - Schaefer, Franz

PY - 2015/8/7

Y1 - 2015/8/7

N2 - Background and objectives Newer parameters of cardiac mechanics provide additional insights on cardiac dysfunction in adult patients with CKD. The aim of this study was to identify prevalence of subclinical abnormalities in cardiac function through the analysis of novel indices of cardiac mechanics in a large population of children with CKD. Design, setting, participants, & measurements Between 2009 and 2011, the prospective observational Cardiovascular Comorbidity in Children with CKD Study enrolled patients with CKD ages 6–17 years old with eGFR=10–45 ml/min per 1.73 m2 in 14 European countries. Cardiac morphology and function were assessed through echocardiography. The analysis presented encompasses global radial, longitudinal, and circumferential strains as well as time to peak analysis. Data were compared with 61 healthy children with comparable age and sex. Results Data on 272 patients with CKD with complete echocardiographic assessment are reported (age =12.8±3.5 years old; 65% boys). Patients with CKD showed mildly higher office BP values and higher prevalence of left ventricular hypertrophy, but no differences were observed among groups in left ventricular ejection fraction. Strain analysis showed significantly lower global radial strain (29.6%±13.3% versus 35.5%±8.9%) and circumferential strain components (−21.8%±4.8% versus −28.2%±5.0%; both P

AB - Background and objectives Newer parameters of cardiac mechanics provide additional insights on cardiac dysfunction in adult patients with CKD. The aim of this study was to identify prevalence of subclinical abnormalities in cardiac function through the analysis of novel indices of cardiac mechanics in a large population of children with CKD. Design, setting, participants, & measurements Between 2009 and 2011, the prospective observational Cardiovascular Comorbidity in Children with CKD Study enrolled patients with CKD ages 6–17 years old with eGFR=10–45 ml/min per 1.73 m2 in 14 European countries. Cardiac morphology and function were assessed through echocardiography. The analysis presented encompasses global radial, longitudinal, and circumferential strains as well as time to peak analysis. Data were compared with 61 healthy children with comparable age and sex. Results Data on 272 patients with CKD with complete echocardiographic assessment are reported (age =12.8±3.5 years old; 65% boys). Patients with CKD showed mildly higher office BP values and higher prevalence of left ventricular hypertrophy, but no differences were observed among groups in left ventricular ejection fraction. Strain analysis showed significantly lower global radial strain (29.6%±13.3% versus 35.5%±8.9%) and circumferential strain components (−21.8%±4.8% versus −28.2%±5.0%; both P

UR - http://www.scopus.com/inward/record.url?scp=84938882159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938882159&partnerID=8YFLogxK

U2 - 10.2215/CJN.10921114

DO - 10.2215/CJN.10921114

M3 - Article

AN - SCOPUS:84938882159

VL - 10

SP - 1357

EP - 1363

JO - Clinical journal of the American Society of Nephrology : CJASN

JF - Clinical journal of the American Society of Nephrology : CJASN

SN - 1555-9041

IS - 8

ER -