Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

Martin J. Hoogduijn, Felix C. Popp, Anja Grohnert, Meindert J. Crop, Marieke Van Rhijn, Ajda T. Rowshani, Elke Eggenhofer, Philipp Renner, Marlies E. Reinders, Ton J. Rabelink, Luc J W Van Der Laan, Frank J M F Dor, Jan N M Ijzermans, Paul G. Genever, Claudia Lange, Antoine Durrbach, Jaco H. Houtgraaf, Bruno Christ, Martina Seifert, Murat ShagidulinVincent Donckier, Robert Deans, Olle Ringden, Norberto Perico, Giuseppe Remuzzi, Amelia Bartholomew, Hans J. Schlitt, Willem Weimar, Carla C. Baan, Marc H. Dahlke

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.

Original languageEnglish
Pages (from-to)124-126
Number of pages3
JournalTransplantation
Volume90
Issue number2
DOIs
Publication statusPublished - Jul 27 2010

Fingerprint

Organ Transplantation
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
Graft Survival
Transplantation
Safety

Keywords

  • Clinical trial
  • Mesenchymal stem cell
  • MISOT
  • Solid organ transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Hoogduijn, M. J., Popp, F. C., Grohnert, A., Crop, M. J., Van Rhijn, M., Rowshani, A. T., ... Dahlke, M. H. (2010). Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). Transplantation, 90(2), 124-126. https://doi.org/10.1097/TP.0b013e3181ea4240

Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). / Hoogduijn, Martin J.; Popp, Felix C.; Grohnert, Anja; Crop, Meindert J.; Van Rhijn, Marieke; Rowshani, Ajda T.; Eggenhofer, Elke; Renner, Philipp; Reinders, Marlies E.; Rabelink, Ton J.; Van Der Laan, Luc J W; Dor, Frank J M F; Ijzermans, Jan N M; Genever, Paul G.; Lange, Claudia; Durrbach, Antoine; Houtgraaf, Jaco H.; Christ, Bruno; Seifert, Martina; Shagidulin, Murat; Donckier, Vincent; Deans, Robert; Ringden, Olle; Perico, Norberto; Remuzzi, Giuseppe; Bartholomew, Amelia; Schlitt, Hans J.; Weimar, Willem; Baan, Carla C.; Dahlke, Marc H.

In: Transplantation, Vol. 90, No. 2, 27.07.2010, p. 124-126.

Research output: Contribution to journalArticle

Hoogduijn, MJ, Popp, FC, Grohnert, A, Crop, MJ, Van Rhijn, M, Rowshani, AT, Eggenhofer, E, Renner, P, Reinders, ME, Rabelink, TJ, Van Der Laan, LJW, Dor, FJMF, Ijzermans, JNM, Genever, PG, Lange, C, Durrbach, A, Houtgraaf, JH, Christ, B, Seifert, M, Shagidulin, M, Donckier, V, Deans, R, Ringden, O, Perico, N, Remuzzi, G, Bartholomew, A, Schlitt, HJ, Weimar, W, Baan, CC & Dahlke, MH 2010, 'Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)', Transplantation, vol. 90, no. 2, pp. 124-126. https://doi.org/10.1097/TP.0b013e3181ea4240
Hoogduijn MJ, Popp FC, Grohnert A, Crop MJ, Van Rhijn M, Rowshani AT et al. Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). Transplantation. 2010 Jul 27;90(2):124-126. https://doi.org/10.1097/TP.0b013e3181ea4240
Hoogduijn, Martin J. ; Popp, Felix C. ; Grohnert, Anja ; Crop, Meindert J. ; Van Rhijn, Marieke ; Rowshani, Ajda T. ; Eggenhofer, Elke ; Renner, Philipp ; Reinders, Marlies E. ; Rabelink, Ton J. ; Van Der Laan, Luc J W ; Dor, Frank J M F ; Ijzermans, Jan N M ; Genever, Paul G. ; Lange, Claudia ; Durrbach, Antoine ; Houtgraaf, Jaco H. ; Christ, Bruno ; Seifert, Martina ; Shagidulin, Murat ; Donckier, Vincent ; Deans, Robert ; Ringden, Olle ; Perico, Norberto ; Remuzzi, Giuseppe ; Bartholomew, Amelia ; Schlitt, Hans J. ; Weimar, Willem ; Baan, Carla C. ; Dahlke, Marc H. / Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). In: Transplantation. 2010 ; Vol. 90, No. 2. pp. 124-126.
@article{c0bada4f98be45489ca3480999da56b4,
title = "Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)",
abstract = "There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.",
keywords = "Clinical trial, Mesenchymal stem cell, MISOT, Solid organ transplantation",
author = "Hoogduijn, {Martin J.} and Popp, {Felix C.} and Anja Grohnert and Crop, {Meindert J.} and {Van Rhijn}, Marieke and Rowshani, {Ajda T.} and Elke Eggenhofer and Philipp Renner and Reinders, {Marlies E.} and Rabelink, {Ton J.} and {Van Der Laan}, {Luc J W} and Dor, {Frank J M F} and Ijzermans, {Jan N M} and Genever, {Paul G.} and Claudia Lange and Antoine Durrbach and Houtgraaf, {Jaco H.} and Bruno Christ and Martina Seifert and Murat Shagidulin and Vincent Donckier and Robert Deans and Olle Ringden and Norberto Perico and Giuseppe Remuzzi and Amelia Bartholomew and Schlitt, {Hans J.} and Willem Weimar and Baan, {Carla C.} and Dahlke, {Marc H.}",
year = "2010",
month = "7",
day = "27",
doi = "10.1097/TP.0b013e3181ea4240",
language = "English",
volume = "90",
pages = "124--126",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

AU - Hoogduijn, Martin J.

AU - Popp, Felix C.

AU - Grohnert, Anja

AU - Crop, Meindert J.

AU - Van Rhijn, Marieke

AU - Rowshani, Ajda T.

AU - Eggenhofer, Elke

AU - Renner, Philipp

AU - Reinders, Marlies E.

AU - Rabelink, Ton J.

AU - Van Der Laan, Luc J W

AU - Dor, Frank J M F

AU - Ijzermans, Jan N M

AU - Genever, Paul G.

AU - Lange, Claudia

AU - Durrbach, Antoine

AU - Houtgraaf, Jaco H.

AU - Christ, Bruno

AU - Seifert, Martina

AU - Shagidulin, Murat

AU - Donckier, Vincent

AU - Deans, Robert

AU - Ringden, Olle

AU - Perico, Norberto

AU - Remuzzi, Giuseppe

AU - Bartholomew, Amelia

AU - Schlitt, Hans J.

AU - Weimar, Willem

AU - Baan, Carla C.

AU - Dahlke, Marc H.

PY - 2010/7/27

Y1 - 2010/7/27

N2 - There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.

AB - There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.

KW - Clinical trial

KW - Mesenchymal stem cell

KW - MISOT

KW - Solid organ transplantation

UR - http://www.scopus.com/inward/record.url?scp=77954957825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954957825&partnerID=8YFLogxK

U2 - 10.1097/TP.0b013e3181ea4240

DO - 10.1097/TP.0b013e3181ea4240

M3 - Article

C2 - 20606604

AN - SCOPUS:77954957825

VL - 90

SP - 124

EP - 126

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 2

ER -