Advancements in Omics Sciences

Adriana Amaro, Andrea Petretto, Giovanna Angelini, Ulrich Pfeffer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The increased knowledge of the biology of the human organism, its physiology, and pathological degeneration, and the deciphering of the genetic code of the human cell combined with modern microengineering and bioinformatics have led to analytical approaches that address the biological complexity with limited a priori reduction. Instead of analyzing single gene, protein, or metabolite, their entirety, the genome, the proteome, or the metabolome, is analyzed. In accordance with the suffix "-ome" indicating the entirety, these approaches are grouped together under the label "omics." Omics are applied in translational medicine where research findings are to be translated into clinically meaningful applications based on their intrinsic potential for personalized medicine. Diagnosis, prognostication, and therapy response prediction can be assessed in an unbiased fashion applying omics allowing for personalization of medicine from risk evaluation to the management of therapy resistance.

Original languageEnglish
Title of host publicationTranslational Medicine
Subtitle of host publicationTools and Techniques
PublisherElsevier
Pages67-108
Number of pages42
ISBN (Electronic)9780128034941
ISBN (Print)9780128034606
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Translational Medical Research
Medicine
Genetic Code
Precision Medicine
Metabolome
Proteome
Computational Biology
Bioelectric potentials
Physiology
Genome
Bioinformatics
Metabolites
Labels
Therapeutics
Genes
Cells
Proteins
benzoylprop-ethyl

Keywords

  • Bioinformatics
  • Epigenomics
  • Genomics
  • Metabolomics
  • Microarray
  • Next-generation sequencing
  • Proteomics
  • Systems biology
  • Transcriptomics

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Amaro, A., Petretto, A., Angelini, G., & Pfeffer, U. (2015). Advancements in Omics Sciences. In Translational Medicine: Tools and Techniques (pp. 67-108). Elsevier. https://doi.org/10.1016/B978-0-12-803460-6.00004-0

Advancements in Omics Sciences. / Amaro, Adriana; Petretto, Andrea; Angelini, Giovanna; Pfeffer, Ulrich.

Translational Medicine: Tools and Techniques. Elsevier, 2015. p. 67-108.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amaro, A, Petretto, A, Angelini, G & Pfeffer, U 2015, Advancements in Omics Sciences. in Translational Medicine: Tools and Techniques. Elsevier, pp. 67-108. https://doi.org/10.1016/B978-0-12-803460-6.00004-0
Amaro A, Petretto A, Angelini G, Pfeffer U. Advancements in Omics Sciences. In Translational Medicine: Tools and Techniques. Elsevier. 2015. p. 67-108 https://doi.org/10.1016/B978-0-12-803460-6.00004-0
Amaro, Adriana ; Petretto, Andrea ; Angelini, Giovanna ; Pfeffer, Ulrich. / Advancements in Omics Sciences. Translational Medicine: Tools and Techniques. Elsevier, 2015. pp. 67-108
@inbook{170fd6d799554f92bc463d896cbccc35,
title = "Advancements in Omics Sciences",
abstract = "The increased knowledge of the biology of the human organism, its physiology, and pathological degeneration, and the deciphering of the genetic code of the human cell combined with modern microengineering and bioinformatics have led to analytical approaches that address the biological complexity with limited a priori reduction. Instead of analyzing single gene, protein, or metabolite, their entirety, the genome, the proteome, or the metabolome, is analyzed. In accordance with the suffix {"}-ome{"} indicating the entirety, these approaches are grouped together under the label {"}omics.{"} Omics are applied in translational medicine where research findings are to be translated into clinically meaningful applications based on their intrinsic potential for personalized medicine. Diagnosis, prognostication, and therapy response prediction can be assessed in an unbiased fashion applying omics allowing for personalization of medicine from risk evaluation to the management of therapy resistance.",
keywords = "Bioinformatics, Epigenomics, Genomics, Metabolomics, Microarray, Next-generation sequencing, Proteomics, Systems biology, Transcriptomics",
author = "Adriana Amaro and Andrea Petretto and Giovanna Angelini and Ulrich Pfeffer",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/B978-0-12-803460-6.00004-0",
language = "English",
isbn = "9780128034606",
pages = "67--108",
booktitle = "Translational Medicine",
publisher = "Elsevier",
address = "Netherlands",

}

TY - CHAP

T1 - Advancements in Omics Sciences

AU - Amaro, Adriana

AU - Petretto, Andrea

AU - Angelini, Giovanna

AU - Pfeffer, Ulrich

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The increased knowledge of the biology of the human organism, its physiology, and pathological degeneration, and the deciphering of the genetic code of the human cell combined with modern microengineering and bioinformatics have led to analytical approaches that address the biological complexity with limited a priori reduction. Instead of analyzing single gene, protein, or metabolite, their entirety, the genome, the proteome, or the metabolome, is analyzed. In accordance with the suffix "-ome" indicating the entirety, these approaches are grouped together under the label "omics." Omics are applied in translational medicine where research findings are to be translated into clinically meaningful applications based on their intrinsic potential for personalized medicine. Diagnosis, prognostication, and therapy response prediction can be assessed in an unbiased fashion applying omics allowing for personalization of medicine from risk evaluation to the management of therapy resistance.

AB - The increased knowledge of the biology of the human organism, its physiology, and pathological degeneration, and the deciphering of the genetic code of the human cell combined with modern microengineering and bioinformatics have led to analytical approaches that address the biological complexity with limited a priori reduction. Instead of analyzing single gene, protein, or metabolite, their entirety, the genome, the proteome, or the metabolome, is analyzed. In accordance with the suffix "-ome" indicating the entirety, these approaches are grouped together under the label "omics." Omics are applied in translational medicine where research findings are to be translated into clinically meaningful applications based on their intrinsic potential for personalized medicine. Diagnosis, prognostication, and therapy response prediction can be assessed in an unbiased fashion applying omics allowing for personalization of medicine from risk evaluation to the management of therapy resistance.

KW - Bioinformatics

KW - Epigenomics

KW - Genomics

KW - Metabolomics

KW - Microarray

KW - Next-generation sequencing

KW - Proteomics

KW - Systems biology

KW - Transcriptomics

UR - http://www.scopus.com/inward/record.url?scp=85017456559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017456559&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-803460-6.00004-0

DO - 10.1016/B978-0-12-803460-6.00004-0

M3 - Chapter

AN - SCOPUS:85017456559

SN - 9780128034606

SP - 67

EP - 108

BT - Translational Medicine

PB - Elsevier

ER -