Advances in diagnosis and therapy of neuroendocrine tumors

Emilio Bajetta, Giuseppe Procopio, Roberto Buzzoni, Laura Catena, Leonardo Ferrari, Michele Del Vecchio

Research output: Contribution to journalArticle

Abstract

Neuroendocrine tumors represent a group of neoplasias characterized by significant histopathologic and biological heterogeneity. Diagnosis of neuroendocrine tumors relies upon histological examination augmented by newer techniques such as positron emission tomography, meta-iodobenzylguanidine scintigraphy or octreoscan. Surgery represents the definite and curative therapeutic approach in early phase tumors. In metastatic or advanced disease, medical treatment is the best choice. Somatostatin analogs allow adequate control of the carcinoid syndrome, without a significant effect on tumor cell growth. Interferon-α may represent an alternative, alone or in association with somatostatin analogs. Chemotherapy is the best choice in the treatment of neuroendocrine tumors characterized by a poor differentiation grade and a high proliferation rate.

Original languageEnglish
Pages (from-to)371-381
Number of pages11
JournalExpert Review of Anticancer Therapy
Volume1
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Antracyclines
  • Dacarbazine
  • Etoposide
  • Fluoropyrimidines
  • Interferon
  • Lanreotide
  • Neuroendocrine tumors
  • Octreotide
  • Platin Analogs

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

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