Advances in diagnostics and outcome measures in peripheral neuropathies

Ingemar S J Merkies, Catharina G. Faber, Giuseppe Lauria

Research output: Contribution to journalArticlepeer-review


Peripheral neuropathies are a group of acquired and hereditary disorders presenting with different distribution and nerve fiber class involvement. The overall prevalence is 2.4%, increasing to 8% in the elderly population. However, the frequency may vary depending on the underlying pathogenesis and association with systemic diseases. Distal symmetric polyneuropathy is the most common form, though multiple mononeuropathies, non-length dependent neuropathy and small fiber neuropathy can occur and may require specific diagnostic tools. The use of uniform outcome measures in peripheral neuropathies is important to improve the quality of randomized controlled trials, enabling comparison between studies. Recent developments in defining the optimal set of outcome measures in inflammatory neuropathies may serve as an example for other conditions. Diagnostic and outcome measure advances in peripheral neuropathies will be discussed.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalNeuroscience Letters
Publication statusPublished - Jun 2 2015


  • Cardiac scintigraphy
  • Confocal corneal microscopy
  • Evoked potential
  • Imaging
  • Neuropathy
  • Outcome measures
  • Quantitative sensory testing
  • Skin biopsy
  • Sodium channel genes
  • Ultrasounds

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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