Advances in molecular preclinical therapy mediated by imaging

Adelaide Greco, Sandra Albanese, Luigi Auletta, Flavia De Carlo, Marco Salvatore, Candace M. Howard, Pier Paolo Claudio

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored different molecular alterations. Personalized therapy and the development of advanced techniques of preclinical imaging and new murine models of disease are emerging concepts that are allowing mapping of disease markers in vivo and in some cases also receptor targeted therapy. Aim of this review is to illustrate some emerging models of disease that allow patient tumor implantation in mice for subsequent drug testing and advanced approaches for therapy mediated by preclinical imaging. In particular we discuss targeted therapy mediated by high frequency ultrasound and magnetic resonance, two emerging techniques in molecular preclinical therapy.

Original languageEnglish
Pages (from-to)76-94
Number of pages19
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume61
Issue number1
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

Neoplasms
Therapeutics
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations

Keywords

  • Gene therapy
  • Magnetic resonance imaging
  • Molecular imaging
  • Molecular targeted therapy
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)
  • Radiology Nuclear Medicine and imaging

Cite this

Advances in molecular preclinical therapy mediated by imaging. / Greco, Adelaide; Albanese, Sandra; Auletta, Luigi; De Carlo, Flavia; Salvatore, Marco; Howard, Candace M.; Claudio, Pier Paolo.

In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 61, No. 1, 01.03.2017, p. 76-94.

Research output: Contribution to journalReview article

Greco, Adelaide ; Albanese, Sandra ; Auletta, Luigi ; De Carlo, Flavia ; Salvatore, Marco ; Howard, Candace M. ; Claudio, Pier Paolo. / Advances in molecular preclinical therapy mediated by imaging. In: Quarterly Journal of Nuclear Medicine and Molecular Imaging. 2017 ; Vol. 61, No. 1. pp. 76-94.
@article{ec8b6ca62dc44ca78b402dd958f58427,
title = "Advances in molecular preclinical therapy mediated by imaging",
abstract = "Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored different molecular alterations. Personalized therapy and the development of advanced techniques of preclinical imaging and new murine models of disease are emerging concepts that are allowing mapping of disease markers in vivo and in some cases also receptor targeted therapy. Aim of this review is to illustrate some emerging models of disease that allow patient tumor implantation in mice for subsequent drug testing and advanced approaches for therapy mediated by preclinical imaging. In particular we discuss targeted therapy mediated by high frequency ultrasound and magnetic resonance, two emerging techniques in molecular preclinical therapy.",
keywords = "Gene therapy, Magnetic resonance imaging, Molecular imaging, Molecular targeted therapy, Ultrasonography",
author = "Adelaide Greco and Sandra Albanese and Luigi Auletta and {De Carlo}, Flavia and Marco Salvatore and Howard, {Candace M.} and Claudio, {Pier Paolo}",
year = "2017",
month = "3",
day = "1",
doi = "10.23736/S1824-4785.16.02944-7",
language = "English",
volume = "61",
pages = "76--94",
journal = "Quarterly Journal of Nuclear Medicine and Molecular Imaging",
issn = "1824-4785",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "1",

}

TY - JOUR

T1 - Advances in molecular preclinical therapy mediated by imaging

AU - Greco, Adelaide

AU - Albanese, Sandra

AU - Auletta, Luigi

AU - De Carlo, Flavia

AU - Salvatore, Marco

AU - Howard, Candace M.

AU - Claudio, Pier Paolo

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored different molecular alterations. Personalized therapy and the development of advanced techniques of preclinical imaging and new murine models of disease are emerging concepts that are allowing mapping of disease markers in vivo and in some cases also receptor targeted therapy. Aim of this review is to illustrate some emerging models of disease that allow patient tumor implantation in mice for subsequent drug testing and advanced approaches for therapy mediated by preclinical imaging. In particular we discuss targeted therapy mediated by high frequency ultrasound and magnetic resonance, two emerging techniques in molecular preclinical therapy.

AB - Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored different molecular alterations. Personalized therapy and the development of advanced techniques of preclinical imaging and new murine models of disease are emerging concepts that are allowing mapping of disease markers in vivo and in some cases also receptor targeted therapy. Aim of this review is to illustrate some emerging models of disease that allow patient tumor implantation in mice for subsequent drug testing and advanced approaches for therapy mediated by preclinical imaging. In particular we discuss targeted therapy mediated by high frequency ultrasound and magnetic resonance, two emerging techniques in molecular preclinical therapy.

KW - Gene therapy

KW - Magnetic resonance imaging

KW - Molecular imaging

KW - Molecular targeted therapy

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=85014349390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014349390&partnerID=8YFLogxK

U2 - 10.23736/S1824-4785.16.02944-7

DO - 10.23736/S1824-4785.16.02944-7

M3 - Review article

AN - SCOPUS:85014349390

VL - 61

SP - 76

EP - 94

JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging

JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging

SN - 1824-4785

IS - 1

ER -