Advances in the epidemiology of HIV-associated non-Hodgkin's lymphoma and other lymphoid neoplasms

Silvia Franceschi, Luigino D. Dal Maso, Carlo L. La Vecchia

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The spectrum of HIV-related lymphoid malignancies certainly includes non-Hodgkin's lymphoma (NHL; i.e., chiefly large-cell lymphoma and Burkitt's lymphoma), primary lymphoma of the brain (PBL) and, possibly, Hodgkin's disease (HD). Since the mid-1990s, several epidemiological studies have led to better quantification of the burden of lymphomas in HIV-infected populations. AIDS surveillance data from 17 western European countries show that between 1988 and 1997 a total of 7,148 AIDS cases had NHL as the AIDS- defining illness. The yearly number of cases rose steadily from 1988 to 1995 but declined thereafter. As a percentage of AIDS-defining illnesses, NHL increased from 3.6% in 1994 to 4.9% in 1997. Percent increases were observed in different strata by area, age group, sex and HIV-transmission group. To estimate relative risk (RR) of NHL and other lymphoid neoplasms in unselected HIV-seropositive populations, records of population-based cancer registries and AIDS registries were linked in the United States, Italy and Australia. RRs for NHL in adults with HIV/AIDS ranged between 14 (for low-grade NHL) to over 300 (for high-grade NHL). For HD, the RR was approximately 10. Limited findings from studies based on death certificates and cohorts of HIV- seropositive persons were consistent with those from registry linkage studies. In developing countries, the risk of HIV-associated NHL appears to be much lower than in developed countries, but under-ascertainment and earlier death from other AIDS manifestations may explain the lack of HIV- associated lymphomas in Africa.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalInternational Journal of Cancer
Volume83
Issue number4
DOIs
Publication statusPublished - 1999

Fingerprint

Non-Hodgkin's Lymphoma
Epidemiology
HIV
Acquired Immunodeficiency Syndrome
Lymphoma
Neoplasms
Registries
Hodgkin Disease
Developing Countries
Population
Death Certificates
Burkitt Lymphoma
Italy
Epidemiologic Studies
Age Groups
Brain

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Advances in the epidemiology of HIV-associated non-Hodgkin's lymphoma and other lymphoid neoplasms. / Franceschi, Silvia; Dal Maso, Luigino D.; La Vecchia, Carlo L.

In: International Journal of Cancer, Vol. 83, No. 4, 1999, p. 481-485.

Research output: Contribution to journalArticle

@article{d2f94e68a14344f9ad1841d8a02e56c4,
title = "Advances in the epidemiology of HIV-associated non-Hodgkin's lymphoma and other lymphoid neoplasms",
abstract = "The spectrum of HIV-related lymphoid malignancies certainly includes non-Hodgkin's lymphoma (NHL; i.e., chiefly large-cell lymphoma and Burkitt's lymphoma), primary lymphoma of the brain (PBL) and, possibly, Hodgkin's disease (HD). Since the mid-1990s, several epidemiological studies have led to better quantification of the burden of lymphomas in HIV-infected populations. AIDS surveillance data from 17 western European countries show that between 1988 and 1997 a total of 7,148 AIDS cases had NHL as the AIDS- defining illness. The yearly number of cases rose steadily from 1988 to 1995 but declined thereafter. As a percentage of AIDS-defining illnesses, NHL increased from 3.6{\%} in 1994 to 4.9{\%} in 1997. Percent increases were observed in different strata by area, age group, sex and HIV-transmission group. To estimate relative risk (RR) of NHL and other lymphoid neoplasms in unselected HIV-seropositive populations, records of population-based cancer registries and AIDS registries were linked in the United States, Italy and Australia. RRs for NHL in adults with HIV/AIDS ranged between 14 (for low-grade NHL) to over 300 (for high-grade NHL). For HD, the RR was approximately 10. Limited findings from studies based on death certificates and cohorts of HIV- seropositive persons were consistent with those from registry linkage studies. In developing countries, the risk of HIV-associated NHL appears to be much lower than in developed countries, but under-ascertainment and earlier death from other AIDS manifestations may explain the lack of HIV- associated lymphomas in Africa.",
author = "Silvia Franceschi and {Dal Maso}, {Luigino D.} and {La Vecchia}, {Carlo L.}",
year = "1999",
doi = "10.1002/(SICI)1097-0215(19991112)83:4<481::AID-IJC8>3.0.CO;2-5",
language = "English",
volume = "83",
pages = "481--485",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Advances in the epidemiology of HIV-associated non-Hodgkin's lymphoma and other lymphoid neoplasms

AU - Franceschi, Silvia

AU - Dal Maso, Luigino D.

AU - La Vecchia, Carlo L.

PY - 1999

Y1 - 1999

N2 - The spectrum of HIV-related lymphoid malignancies certainly includes non-Hodgkin's lymphoma (NHL; i.e., chiefly large-cell lymphoma and Burkitt's lymphoma), primary lymphoma of the brain (PBL) and, possibly, Hodgkin's disease (HD). Since the mid-1990s, several epidemiological studies have led to better quantification of the burden of lymphomas in HIV-infected populations. AIDS surveillance data from 17 western European countries show that between 1988 and 1997 a total of 7,148 AIDS cases had NHL as the AIDS- defining illness. The yearly number of cases rose steadily from 1988 to 1995 but declined thereafter. As a percentage of AIDS-defining illnesses, NHL increased from 3.6% in 1994 to 4.9% in 1997. Percent increases were observed in different strata by area, age group, sex and HIV-transmission group. To estimate relative risk (RR) of NHL and other lymphoid neoplasms in unselected HIV-seropositive populations, records of population-based cancer registries and AIDS registries were linked in the United States, Italy and Australia. RRs for NHL in adults with HIV/AIDS ranged between 14 (for low-grade NHL) to over 300 (for high-grade NHL). For HD, the RR was approximately 10. Limited findings from studies based on death certificates and cohorts of HIV- seropositive persons were consistent with those from registry linkage studies. In developing countries, the risk of HIV-associated NHL appears to be much lower than in developed countries, but under-ascertainment and earlier death from other AIDS manifestations may explain the lack of HIV- associated lymphomas in Africa.

AB - The spectrum of HIV-related lymphoid malignancies certainly includes non-Hodgkin's lymphoma (NHL; i.e., chiefly large-cell lymphoma and Burkitt's lymphoma), primary lymphoma of the brain (PBL) and, possibly, Hodgkin's disease (HD). Since the mid-1990s, several epidemiological studies have led to better quantification of the burden of lymphomas in HIV-infected populations. AIDS surveillance data from 17 western European countries show that between 1988 and 1997 a total of 7,148 AIDS cases had NHL as the AIDS- defining illness. The yearly number of cases rose steadily from 1988 to 1995 but declined thereafter. As a percentage of AIDS-defining illnesses, NHL increased from 3.6% in 1994 to 4.9% in 1997. Percent increases were observed in different strata by area, age group, sex and HIV-transmission group. To estimate relative risk (RR) of NHL and other lymphoid neoplasms in unselected HIV-seropositive populations, records of population-based cancer registries and AIDS registries were linked in the United States, Italy and Australia. RRs for NHL in adults with HIV/AIDS ranged between 14 (for low-grade NHL) to over 300 (for high-grade NHL). For HD, the RR was approximately 10. Limited findings from studies based on death certificates and cohorts of HIV- seropositive persons were consistent with those from registry linkage studies. In developing countries, the risk of HIV-associated NHL appears to be much lower than in developed countries, but under-ascertainment and earlier death from other AIDS manifestations may explain the lack of HIV- associated lymphomas in Africa.

UR - http://www.scopus.com/inward/record.url?scp=0032836013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032836013&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0215(19991112)83:4<481::AID-IJC8>3.0.CO;2-5

DO - 10.1002/(SICI)1097-0215(19991112)83:4<481::AID-IJC8>3.0.CO;2-5

M3 - Article

VL - 83

SP - 481

EP - 485

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -