Advances in the pathogenesis and treatment of pulmonary alveolar proteinosis

M. Luisetti

Research output: Contribution to journalArticlepeer-review


Pulmonary alveolar proteinosis is a rare condition characterized by accumulation of surfactant components, both proteins and phospholipids, within alveoli and distal airways, leading to impairment of gas exchange and eventually to respiratory failure in approximately one third of carriers. The natural history of the disease has been dramatically changed by the whole lung lavage. Studies performed using transgenic animals suggest that granulocyte-macrophage colony-stimulating factors may play a role in the development of the disease, thus opening the way to innovative therapeutic strategies.

Original languageEnglish
Pages (from-to)117-119
Number of pages3
JournalStudia Pneumologica et Phtiseologica
Issue number3
Publication statusPublished - 1997


  • Granulocyte-macrophage colony-stimulating factor
  • Surfactant protein A
  • Transgenic animals
  • Whole lung lavage

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Advances in the pathogenesis and treatment of pulmonary alveolar proteinosis'. Together they form a unique fingerprint.

Cite this