Advances in the research and development of chemotherapeutic agents for respiratory tract bacterial infections

Mario Cazzola, Francesco Blasi, Stefano Centanni, Claudio Ferdinando Donner, Luigi Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

The activity of existing antibiotics is diminishing due to the increasing number of resistant strains and by the increase of infections with naturally resistant microorganisms. New agents are urgently needed to meet this challenge and the molecular strategies adopted for the discovery of these compounds must focus on minimizing the emergence of future resistance to them. Novel compounds can be grouped on the basis of their mechanism of action: inhibitors of nucleic acid synthesis (fluoroquinolones), inhibitors of protein synthesis (ketolides, oxazolidinones, streptogramins, and glycylcyclines), inhibitors of peptidoglycan synthesis (β-lactams and glycopeptides), and agents interfering with membrane function (cationic peptides, and lipopeptides). Regarding the agents that are already in the research and development pipeline, only the oxazolidinones, the cationic peptides and the lipopeptide antibiotics can be truly considered as structurally novel inhibitors because the other agents are analogues of existing compounds that have been in use for many years.

Original languageEnglish
Pages (from-to)367-381
Number of pages15
JournalPulmonary Pharmacology and Therapeutics
Volume14
Issue number5
DOIs
Publication statusPublished - 2001

Keywords

  • β-lactams
  • Antimicrobial resistance
  • Cationic peptides
  • Fluoroquinolones
  • Glycopeptides
  • Glycylcyclines
  • Ketolides
  • Lipopeptides
  • Lower respiratory tract infections
  • Novel compounds
  • Oxazolidinones
  • Streptogramins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology

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