Advances in the treatment of mania

P. Brambilla, J. C. Soares

Research output: Contribution to journalArticlepeer-review


Lithium is, to this date, still the first choice in the treatment of acute mania, while valproate and carbamazepine are generally very useful second options. Ideally, it is best if the drug used in the acute treatment phase can also be maintained during the prophylactic phase of treatment, possibly as monotherapy. In poor responders, antipsychotics, benzodiazepines, or both may be added to the first-line mood stabilizer for short periods of time. Newer anticonvulsants and calcium channel blockers may also be considered for treatment-resistant subjects, but their efficacy needs to be further evaluated in controlled studies.

Original languageEnglish
Pages (from-to)155-180
Number of pages26
JournalPsychiatric Clinics of North America: Annual of Drug Therapy
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology


Dive into the research topics of 'Advances in the treatment of mania'. Together they form a unique fingerprint.

Cite this