TY - JOUR
T1 - Advances in understanding and treating cardiac cachexia
T2 - Highlights from the 5th cachexia conference
AU - Von Haehling, Stephan
AU - Stepney, Rob
AU - Anker, Stefan D.
PY - 2010/10/29
Y1 - 2010/10/29
N2 - Cardiac cachexia as a terminal stage of chronic heart failure carries a devastating prognosis. This article focuses on novel insights into the pathophysiology and on new treatment aproaches to cardiac cachexia. Drugs that have been used in preclinical and clinical studies that may also confer beneficial effects in cardiac cachexia include but are not limited to the type 4 melanocortin receptor antagonist SNT 207979, the appetite promoting synthetic ghrelin SUN11031, the soluble myostatin decoy receptor ActRIIB-Fc, the fast skeletal muscle troponin activating substance CK-2017357, the anti-catabolic/anabolic transforming agent MT-102, the anti-inflammatory agent celecoxib, and testosterone supplementation.
AB - Cardiac cachexia as a terminal stage of chronic heart failure carries a devastating prognosis. This article focuses on novel insights into the pathophysiology and on new treatment aproaches to cardiac cachexia. Drugs that have been used in preclinical and clinical studies that may also confer beneficial effects in cardiac cachexia include but are not limited to the type 4 melanocortin receptor antagonist SNT 207979, the appetite promoting synthetic ghrelin SUN11031, the soluble myostatin decoy receptor ActRIIB-Fc, the fast skeletal muscle troponin activating substance CK-2017357, the anti-catabolic/anabolic transforming agent MT-102, the anti-inflammatory agent celecoxib, and testosterone supplementation.
KW - Cachexia
KW - Heart failure
KW - Pathophysiology
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=77957886583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957886583&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2010.05.042
DO - 10.1016/j.ijcard.2010.05.042
M3 - Article
C2 - 20561693
AN - SCOPUS:77957886583
VL - 144
SP - 347
EP - 349
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -