Advantage of treating anaplastic gliomas with aggressive protocol combining chemotherapy and radiotherapy

A. Boiardi, A. Silvani, A. Pozzi, M. Farinotti, L. Fariselli, G. Broggi, A. Salmaggi

Research output: Contribution to journalArticlepeer-review


We devised a treatment protocol for anaplastic gliomas consisting of: (a) chemotherapy prior to radiotherapy (b) a second chemotherapy regimen at tumor recurrence (c) repeated surgery whenever possible. 41 Anaplastic Astrocytoma (AA), 16 Anaplastic oligoastrocytoma (AOA) and 14 anaplastic oligodendroglioma (AOD) patients were treated. After surgery all patients received 5-6 cycles of carmustine + Cisplatinum chemotherapy. Radiotherapy was started during the last 2-3 cycles of chemotherapy. 17 patients (30.5%) were reoperated-on at recurrence. All recurring patients underwent PVC chemotherapy. At this moment disease recurred in 56 patients. Median TTP was 24.5, 38.7 and 58.2 months for AA, AOA and AOD respectively. Median ST was 38.8, 71.8 and 73 months. In conclusion our sandwich protocol of prior chemotherapy, overlapping irradiation with second chemotherapy and, in favourable cases, a second surgical intervention, is of benefit in patients with anaplastic gliomas.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalJournal of Neuro-Oncology
Issue number2
Publication statusPublished - 1997


  • Anaplastic gliomas
  • Chemotherapy
  • Prognostic factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)


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