Adverse events after endovascular treatment of chronic cerebro-spinal venous insufficiency (CCSVI) in patients with multiple sclerosis

A. Ghezzi, P. Annovazzi, M. P. Amato, E. Capello, P. Cavalla, E. Cocco, M. Falcini, A. Gallo, F. Patti, P. Perini, M. E. Rodegher, M. Rovaris, M. R. Rottoli, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

Although it is debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients undergo endovascular treatment (ET) of CCSVI. A study is ongoing in Italy to evaluate the clinical outcome of ET. Severe adverse events (AEs) occurred in 15/462 subjects at a variable interval after ET: jugular thrombosis in seven patients, tetraventricular hydrocephalus, stroke, paroxysmal atrial fibrillation, status epilepticus, aspiration pneumonia, hypertension with tachicardia, or bleeding of bedsore in the remaining seven cases. One patient died because of myocardial infarction 10 weeks after ET. The risk of severe AEs related to ET for CCSVI must be carefully considered.

Original languageEnglish
Pages (from-to)961-963
Number of pages3
JournalMultiple Sclerosis Journal
Volume19
Issue number7
DOIs
Publication statusPublished - 2013

Keywords

  • CCSVI
  • endovascular treatment
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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