Adverse events while awaiting myocardial revascularization: A systematic review and meta-analysis

Stuart J. Head, Bruno R. da Costa, Berend Beumer, Giulio G. Stefanini, Fernando Alfonso, Peter M. Clemmensen, Jean Philippe Collet, Jochen Cremer, Volkmar Falk, Gerasimos Filippatos, Christian Hamm, A. Pieter Kappetein, Adnan Kastrati, Juhani Knuuti, Philippe Kolh, Ulf Landmesser, Günther Laufer, Franz Josef Neumann, Dimitrios J. Richter, Patrick SchauerteDavid P. Taggart, Lucia Torracca, Marco Valgimigli, William Wijns, Adam Witkowski, Stephan Windecker, Peter Jüni, Miguel Sousa-Uva

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES: The aim of the current study was to estimate adverse event rates while awaiting myocardial revascularization and review criteria for prioritizing patients. METHODS: A PubMed search was performed on 19 January 2015, to identify English-language, original, observational studies reporting adverse events while awaiting coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Rates of death, nonfatal myocardial infarction (MI) and emergency revascularization were calculated as occurrence rates per 1000 patient-weeks and pooled using random-effects models. RESULTS: The search yielded 1323 articles, of which 22 were included with 66 410 patients and 607 675 patient-weeks on the wait list. When awaiting CABG, rates per 1000 patient-weeks were 1.1 [95% confidence interval 0.9-1.3] for death, 1.0 [0.6-1.6] for non-fatal MI and 1.8 [0.8-4.1] for emergency revascularization. Subgroup analyses demonstrated consistent outcomes, and sensitivity analyses demonstrated comparable event rates with low heterogeneity. Higher urgency of revascularization was based primarily on angiographic complexity, angina severity, left ventricular dysfunction and symptoms on stress testing, and such patients with a semi-urgent status had a higher risk of death than patients awaiting elective revascularization (risk ratio at least 2.8). Individual studies identified angina severity and left ventricular dysfunction as most important predictors of death when awaiting CABG. Adverse rates per 1000 patient-weeks for patients awaiting PCI were 0.1 [95% confidence interval 0.0-0.4] for death, 0.4 [0.1-1.2] for non-fatal MI and 0.7 [0.4-1.4] for emergency revascularization but were based on only a few old studies. CONCLUSIONS: Rates of death, non-fatal MI and emergency revascularization when awaiting myocardial revascularization are infrequent but higher in specific patients. Countries that not yet have treatment recommendations related to waiting times should consider introducing a maximum to limit adverse events, particularly when awaiting CABG.

Original languageEnglish
Article numberezx115
Pages (from-to)206-217
Number of pages12
JournalEuropean Journal of Cardio-thoracic Surgery
Volume52
Issue number2
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Myocardial Revascularization
Meta-Analysis
Coronary Artery Bypass
Emergencies
Myocardial Infarction
Left Ventricular Dysfunction
Percutaneous Coronary Intervention
Confidence Intervals
Mortality
PubMed
Observational Studies
Language
Odds Ratio

Keywords

  • Coronary artery bypass grafting
  • Death
  • Delay
  • Emergency revascularization
  • Myocardial infarction
  • Myocardial revascularization
  • Percutaneous coronary intervention
  • Wait list
  • Waiting

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Head, S. J., da Costa, B. R., Beumer, B., Stefanini, G. G., Alfonso, F., Clemmensen, P. M., ... Sousa-Uva, M. (2017). Adverse events while awaiting myocardial revascularization: A systematic review and meta-analysis. European Journal of Cardio-thoracic Surgery, 52(2), 206-217. [ezx115]. https://doi.org/10.1093/ejcts/ezx115

Adverse events while awaiting myocardial revascularization : A systematic review and meta-analysis. / Head, Stuart J.; da Costa, Bruno R.; Beumer, Berend; Stefanini, Giulio G.; Alfonso, Fernando; Clemmensen, Peter M.; Collet, Jean Philippe; Cremer, Jochen; Falk, Volkmar; Filippatos, Gerasimos; Hamm, Christian; Kappetein, A. Pieter; Kastrati, Adnan; Knuuti, Juhani; Kolh, Philippe; Landmesser, Ulf; Laufer, Günther; Neumann, Franz Josef; Richter, Dimitrios J.; Schauerte, Patrick; Taggart, David P.; Torracca, Lucia; Valgimigli, Marco; Wijns, William; Witkowski, Adam; Windecker, Stephan; Jüni, Peter; Sousa-Uva, Miguel.

In: European Journal of Cardio-thoracic Surgery, Vol. 52, No. 2, ezx115, 01.08.2017, p. 206-217.

Research output: Contribution to journalArticle

Head, SJ, da Costa, BR, Beumer, B, Stefanini, GG, Alfonso, F, Clemmensen, PM, Collet, JP, Cremer, J, Falk, V, Filippatos, G, Hamm, C, Kappetein, AP, Kastrati, A, Knuuti, J, Kolh, P, Landmesser, U, Laufer, G, Neumann, FJ, Richter, DJ, Schauerte, P, Taggart, DP, Torracca, L, Valgimigli, M, Wijns, W, Witkowski, A, Windecker, S, Jüni, P & Sousa-Uva, M 2017, 'Adverse events while awaiting myocardial revascularization: A systematic review and meta-analysis', European Journal of Cardio-thoracic Surgery, vol. 52, no. 2, ezx115, pp. 206-217. https://doi.org/10.1093/ejcts/ezx115
Head, Stuart J. ; da Costa, Bruno R. ; Beumer, Berend ; Stefanini, Giulio G. ; Alfonso, Fernando ; Clemmensen, Peter M. ; Collet, Jean Philippe ; Cremer, Jochen ; Falk, Volkmar ; Filippatos, Gerasimos ; Hamm, Christian ; Kappetein, A. Pieter ; Kastrati, Adnan ; Knuuti, Juhani ; Kolh, Philippe ; Landmesser, Ulf ; Laufer, Günther ; Neumann, Franz Josef ; Richter, Dimitrios J. ; Schauerte, Patrick ; Taggart, David P. ; Torracca, Lucia ; Valgimigli, Marco ; Wijns, William ; Witkowski, Adam ; Windecker, Stephan ; Jüni, Peter ; Sousa-Uva, Miguel. / Adverse events while awaiting myocardial revascularization : A systematic review and meta-analysis. In: European Journal of Cardio-thoracic Surgery. 2017 ; Vol. 52, No. 2. pp. 206-217.
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AU - Head, Stuart J.

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AU - Stefanini, Giulio G.

AU - Alfonso, Fernando

AU - Clemmensen, Peter M.

AU - Collet, Jean Philippe

AU - Cremer, Jochen

AU - Falk, Volkmar

AU - Filippatos, Gerasimos

AU - Hamm, Christian

AU - Kappetein, A. Pieter

AU - Kastrati, Adnan

AU - Knuuti, Juhani

AU - Kolh, Philippe

AU - Landmesser, Ulf

AU - Laufer, Günther

AU - Neumann, Franz Josef

AU - Richter, Dimitrios J.

AU - Schauerte, Patrick

AU - Taggart, David P.

AU - Torracca, Lucia

AU - Valgimigli, Marco

AU - Wijns, William

AU - Witkowski, Adam

AU - Windecker, Stephan

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AU - Sousa-Uva, Miguel

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N2 - OBJECTIVES: The aim of the current study was to estimate adverse event rates while awaiting myocardial revascularization and review criteria for prioritizing patients. METHODS: A PubMed search was performed on 19 January 2015, to identify English-language, original, observational studies reporting adverse events while awaiting coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Rates of death, nonfatal myocardial infarction (MI) and emergency revascularization were calculated as occurrence rates per 1000 patient-weeks and pooled using random-effects models. RESULTS: The search yielded 1323 articles, of which 22 were included with 66 410 patients and 607 675 patient-weeks on the wait list. When awaiting CABG, rates per 1000 patient-weeks were 1.1 [95% confidence interval 0.9-1.3] for death, 1.0 [0.6-1.6] for non-fatal MI and 1.8 [0.8-4.1] for emergency revascularization. Subgroup analyses demonstrated consistent outcomes, and sensitivity analyses demonstrated comparable event rates with low heterogeneity. Higher urgency of revascularization was based primarily on angiographic complexity, angina severity, left ventricular dysfunction and symptoms on stress testing, and such patients with a semi-urgent status had a higher risk of death than patients awaiting elective revascularization (risk ratio at least 2.8). Individual studies identified angina severity and left ventricular dysfunction as most important predictors of death when awaiting CABG. Adverse rates per 1000 patient-weeks for patients awaiting PCI were 0.1 [95% confidence interval 0.0-0.4] for death, 0.4 [0.1-1.2] for non-fatal MI and 0.7 [0.4-1.4] for emergency revascularization but were based on only a few old studies. CONCLUSIONS: Rates of death, non-fatal MI and emergency revascularization when awaiting myocardial revascularization are infrequent but higher in specific patients. Countries that not yet have treatment recommendations related to waiting times should consider introducing a maximum to limit adverse events, particularly when awaiting CABG.

AB - OBJECTIVES: The aim of the current study was to estimate adverse event rates while awaiting myocardial revascularization and review criteria for prioritizing patients. METHODS: A PubMed search was performed on 19 January 2015, to identify English-language, original, observational studies reporting adverse events while awaiting coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Rates of death, nonfatal myocardial infarction (MI) and emergency revascularization were calculated as occurrence rates per 1000 patient-weeks and pooled using random-effects models. RESULTS: The search yielded 1323 articles, of which 22 were included with 66 410 patients and 607 675 patient-weeks on the wait list. When awaiting CABG, rates per 1000 patient-weeks were 1.1 [95% confidence interval 0.9-1.3] for death, 1.0 [0.6-1.6] for non-fatal MI and 1.8 [0.8-4.1] for emergency revascularization. Subgroup analyses demonstrated consistent outcomes, and sensitivity analyses demonstrated comparable event rates with low heterogeneity. Higher urgency of revascularization was based primarily on angiographic complexity, angina severity, left ventricular dysfunction and symptoms on stress testing, and such patients with a semi-urgent status had a higher risk of death than patients awaiting elective revascularization (risk ratio at least 2.8). Individual studies identified angina severity and left ventricular dysfunction as most important predictors of death when awaiting CABG. Adverse rates per 1000 patient-weeks for patients awaiting PCI were 0.1 [95% confidence interval 0.0-0.4] for death, 0.4 [0.1-1.2] for non-fatal MI and 0.7 [0.4-1.4] for emergency revascularization but were based on only a few old studies. CONCLUSIONS: Rates of death, non-fatal MI and emergency revascularization when awaiting myocardial revascularization are infrequent but higher in specific patients. Countries that not yet have treatment recommendations related to waiting times should consider introducing a maximum to limit adverse events, particularly when awaiting CABG.

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KW - Death

KW - Delay

KW - Emergency revascularization

KW - Myocardial infarction

KW - Myocardial revascularization

KW - Percutaneous coronary intervention

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