Adverse haematological outcome and environmental lead poisoning

Vincenzo Fontana, Roberta Baldi, Michela Franchini, Paola Gridelli, Roberto Neri, Franco Palmieri, Riccardo Puntoni, Umberto Ricco, Stefano Parodi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The South-eastern Area (SA) of the Municipality of La Spezia (Liguria Region, Italy) is characterised by a heavy environmental lead (Pb) contamination, chiefly due to the emissions of a Pb-processing plant in operation since 1930. In order to assess the risk of Pb poisoning of residents of SA, and to estimate the degree of association between the blood Pb level (BLL) and haematocrit % (HCT), intended as a biomarker of early haematological dysfunction, we reanalysed data of 785 individuals collected in 1992 as a part of a larger national biological monitoring project. Multiple normal regression modelling was applied to estimate the role of residence on log-transformed BLL, and Median Ratio (MR) was used as an index of effect. The same statistical modelling was also applied to reveal the relationship between HCT and BLL. Allowing for several confounders (including occupational exposure to Pb), residents of SA showed a 14% increase (MR= 1.14, 95% IC = 1.06-1.23%) in the median BLL value compared to people living outside SA. The excess reached 27% (MR = 1.27, 95% IC - 1.14-1.41%) after 30 years of residence. Parallel results were also obtained in a subgroup composed only of pupils (<18 years, non-smokers, non-drinkers). Finally, regression analysis highlighted a statistically significant parabolic trend in HCT in relation to BLL. The non-linear dose-response relationship, which attests to an adverse effect on the erythrocytic function of BLLs at least over 17.00 μg/dl, is in agreement with the findings of other authors and consistent with the results of an excess occurrence of self-reported anaemia obtained from a previous comparative survey carried out on the same population.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalJournal of Exposure Analysis and Environmental Epidemiology
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Industrial poisons
Lead Poisoning
poisoning
Blood
blood
Hematocrit
anemia
Environmental Monitoring
dose-response relationship
occupational exposure
Biomarkers
Occupational Exposure
Pupil
Regression analysis
Poisoning
Italy
modeling
biomarker
Anemia
regression analysis

Keywords

  • Adverse haematological effects
  • Blood lead level
  • Environmental lead pollution

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Adverse haematological outcome and environmental lead poisoning. / Fontana, Vincenzo; Baldi, Roberta; Franchini, Michela; Gridelli, Paola; Neri, Roberto; Palmieri, Franco; Puntoni, Riccardo; Ricco, Umberto; Parodi, Stefano.

In: Journal of Exposure Analysis and Environmental Epidemiology, Vol. 14, No. 2, 03.2004, p. 188-193.

Research output: Contribution to journalArticle

Fontana, V, Baldi, R, Franchini, M, Gridelli, P, Neri, R, Palmieri, F, Puntoni, R, Ricco, U & Parodi, S 2004, 'Adverse haematological outcome and environmental lead poisoning', Journal of Exposure Analysis and Environmental Epidemiology, vol. 14, no. 2, pp. 188-193. https://doi.org/10.1038/sj.jea.7500318
Fontana, Vincenzo ; Baldi, Roberta ; Franchini, Michela ; Gridelli, Paola ; Neri, Roberto ; Palmieri, Franco ; Puntoni, Riccardo ; Ricco, Umberto ; Parodi, Stefano. / Adverse haematological outcome and environmental lead poisoning. In: Journal of Exposure Analysis and Environmental Epidemiology. 2004 ; Vol. 14, No. 2. pp. 188-193.
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