TY - JOUR
T1 - Adverse outcome of coarctation stenting in patients with Turner syndrome
AU - van den Hoven, Allard T.
AU - Duijnhouwer, Anthonie L.
AU - Eicken, Andreas
AU - Aboulhosn, Jamil
AU - de Bruin, Christiaan
AU - Backeljauw, Philippe F.
AU - Demulier, Laurent
AU - Chessa, Massimo
AU - Uebing, Anselm
AU - Veldtman, Gruschen R.
AU - Armstrong, Aimee K.
AU - van den Bosch, Annemien E.
AU - Witsenburg, Maarten
AU - Roos-Hesselink, Jolien W.
PY - 2016
Y1 - 2016
N2 - Objectives: This study examines the outcome and procedural outcomes of percutaneous stent angioplasty for aortic coarctation in patients with Turner syndrome (TS). Background: TS occurs in 1 in 2,500 live-born females and is associated with aortic coarctation. Methods: In this multicenter, retrospective cohort study, all patients with TS and a coarctation of the aorta, treated with percutaneous stent implantation were included. The procedural strategies were dictated by local protocols. Adverse events at short- and long-term follow-up and qualitative parameters concerning the stent implantation were assessed. Results: In the largest study to date of TS patients receiving aortic stents, a total of 19 patients from 10 centers were included. Twelve patients were treated for native and 7 for recurrent coarctation. Age at intervention was 16.9 (7-60) years (median; min-max). The coarctation diameter increased significantly from 8.0 mm (2-12) pre-intervention to 15.0 mm (10-19) post-intervention (P<0.001). Three (15.8%) adverse events occurred within 30 days of the procedure, including two dissections despite the use of covered stents, one resulting in death. At long-term follow-up (6.5 years, min-max: 1-16), two additional deaths occurred not known to be stent-related. Conclusions: Though percutaneous treatment of aortic coarctation in TS patients is effective, it is associated with serious morbidity and mortality. These risks suggest that alternative treatment options should be carefully weighed against percutaneous stenting strategies.
AB - Objectives: This study examines the outcome and procedural outcomes of percutaneous stent angioplasty for aortic coarctation in patients with Turner syndrome (TS). Background: TS occurs in 1 in 2,500 live-born females and is associated with aortic coarctation. Methods: In this multicenter, retrospective cohort study, all patients with TS and a coarctation of the aorta, treated with percutaneous stent implantation were included. The procedural strategies were dictated by local protocols. Adverse events at short- and long-term follow-up and qualitative parameters concerning the stent implantation were assessed. Results: In the largest study to date of TS patients receiving aortic stents, a total of 19 patients from 10 centers were included. Twelve patients were treated for native and 7 for recurrent coarctation. Age at intervention was 16.9 (7-60) years (median; min-max). The coarctation diameter increased significantly from 8.0 mm (2-12) pre-intervention to 15.0 mm (10-19) post-intervention (P<0.001). Three (15.8%) adverse events occurred within 30 days of the procedure, including two dissections despite the use of covered stents, one resulting in death. At long-term follow-up (6.5 years, min-max: 1-16), two additional deaths occurred not known to be stent-related. Conclusions: Though percutaneous treatment of aortic coarctation in TS patients is effective, it is associated with serious morbidity and mortality. These risks suggest that alternative treatment options should be carefully weighed against percutaneous stenting strategies.
KW - Adults
KW - BALA
KW - Balloon angioplasty
KW - Bare metal
KW - BMS
KW - CONA
KW - Congenital heart disease
KW - STEC
KW - Stent
KW - Stenting technique
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U2 - 10.1002/ccd.26728
DO - 10.1002/ccd.26728
M3 - Article
AN - SCOPUS:84993949934
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
SN - 1522-1946
ER -