Adverse outcome of coarctation stenting in patients with Turner syndrome

Allard T van den Hoven, Anthonie L Duijnhouwer, Andreas Eicken, Jamil Aboulhosn, Christiaan de Bruin, Philippe F Backeljauw, Laurent Demulier, Massimo Chessa, Anselm Uebing, Gruschen R Veldtman, Aimee K Armstrong, Annemien E van den Bosch, Maarten Witsenburg, Jolien W Roos-Hesselink

Research output: Contribution to journalReview articlepeer-review


OBJECTIVES: This study examines the outcome and procedural outcomes of percutaneous stent angioplasty for aortic coarctation in patients with Turner syndrome (TS).

BACKGROUND: TS occurs in 1 in 2,500 live-born females and is associated with aortic coarctation.

METHODS: In this multicenter, retrospective cohort study, all patients with TS and a coarctation of the aorta, treated with percutaneous stent implantation were included. The procedural strategies were dictated by local protocols. Adverse events at short- and long-term follow-up and qualitative parameters concerning the stent implantation were assessed.

RESULTS: In the largest study to date of TS patients receiving aortic stents, a total of 19 patients from 10 centers were included. Twelve patients were treated for native and 7 for recurrent coarctation. Age at intervention was 16.9 (7-60) years (median; min-max). The coarctation diameter increased significantly from 8.0 mm (2-12) pre-intervention to 15.0 mm (10-19) post-intervention (P < 0.001). Three (15.8%) adverse events occurred within 30 days of the procedure, including two dissections despite the use of covered stents, one resulting in death. At long-term follow-up (6.5 years, min-max: 1-16), two additional deaths occurred not known to be stent-related.

CONCLUSIONS: Though percutaneous treatment of aortic coarctation in TS patients is effective, it is associated with serious morbidity and mortality. These risks suggest that alternative treatment options should be carefully weighed against percutaneous stenting strategies. © 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)280-287
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Issue number2
Publication statusPublished - Feb 1 2017


  • Adolescent
  • Adult
  • Angioplasty/adverse effects
  • Aortic Coarctation/complications
  • Aortography/methods
  • Child
  • Computed Tomography Angiography
  • Female
  • Humans
  • Middle Aged
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Stents
  • Time Factors
  • Treatment Outcome
  • Turner Syndrome/complications
  • Young Adult


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