Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case-control study: Prenatal Diagnosis

V. Giorgione, V. Fesslova, S. Boveri, M. Candiani, A. Khalil, P. Cavoretto

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The placental development has been shown to be compromised in pregnancies affected by fetal congenital heart defects (CHD). This study aimed to investigate the frequency of complications related to utero-placental insufficiency in pregnancies with and without major CHD. Method: This retrospective case-control study was conducted at a Fetal Echocardiography Center in Milan. The following outcomes were compared between the two groups: preeclampsia (PE), small for gestational age (SGA), placental disorders and preterm birth (PTB). The logistic regression analysis was adjusted for maternal age, parity, co-morbidities and mode of conception. Results: The CHD group (n = 480) showed significantly increased incidence of PE (2.9% vs 0.9%; aOR, 6.50; 95% CI, 1.39-30.41; P =.017) as compared to the control group (n = 456). Placental disorders occurred more frequently in the CHD than in controls, but the increased risk showed only a borderline significance (4.5% vs 3.3%; aOR, 2.56; 95% CI, 0.99-1.02; P =.046). There was a significantly higher risk of SGA in CHD than in controls (8.7% vs 3.9%; aOR, 3.37; 95% CI, 1.51-7.51; P =.003). PTB occurred in 65/477 (13.6%) cases and in 39/447 (8.7%) controls (P =.022) (aOR, 2.17; 95% CI, 1.24-3.81; P =.007). Conclusion: Major CHD are significantly associated with the risk of PE, SGA and PTB. © 2020 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)1390-1397
Number of pages8
JournalPrenat. Diagn.
Volume40
Issue number11
DOIs
Publication statusPublished - 2020

Keywords

  • adult
  • adverse outcome
  • Article
  • atrioventricular septal defect
  • cardiomyopathy
  • case control study
  • congenital heart malformation
  • controlled study
  • echocardiography
  • Fallot tetralogy
  • female
  • fetus
  • heart ventricle septum defect
  • heterotaxy syndrome
  • high risk patient
  • human
  • hypoplastic left heart syndrome
  • incidence
  • major clinical study
  • maternal hypertension
  • perinatal period
  • placenta development
  • placenta disorder
  • placenta insufficiency
  • preeclampsia
  • pregnancy
  • premature labor
  • priority journal
  • retrospective study
  • small for date infant

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