An active surveillance of adverse events following whole-cell diphtheria-tetanus-pertussis immunization (DTP) in the first year of life and of the reasons for interruption of the immunization cycle has been conducted in the period September 1993-April 1995. One thousand seven hundred sixty- five children immunized with different DTP vaccine in the local health units of Veneto and Friuli Venezia Giulia regions participated in the study. Only 19.4% of children with interrupted immunization cycles had an appropriate reason for stopping pertussis vaccination. Moreover 54.2% of children with interrupted pertussis immunization stopped it because of a common adverse event which was not a true contraindication to the administration of further doses. Common adverse events following vaccination ranged from a minimum of 4% of the total doses had vomiting to 58% with irritability. The most frequent severe adverse event was persistent crying > 3 hours (in every 199 doses). Common adverse events following DTP, thugh not representing a true contraindication to the administration of further doses, are a common cause of interruption of the immunization cycle and an obstacle to parental acceptance of vaccination and high vaccination coverage.
|Translated title of the contribution||Adverse reactions to whole-cell pertussis vaccine: A medical or a public health problem?|
|Number of pages||8|
|Publication status||Published - Apr 1999|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health