Advice alone versus structured detoxification programmes for complicated medication overuse headache (MOH): a prospective, randomized, open-label trial.

Paolo Rossi, Jessica Veronica Faroni, Cristina Tassorelli, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to compare the effectiveness of an educational strategy (advice to withdraw the overused medication/s) with that of two structured pharmacological detoxification programmes in patients with complicated medication overuse headache (MOH) plus migraine. One hundred and thirty-seven complicated MOH patients participated in the study. MOH was defined as complicated in patients presenting at least one of the following: a) a diagnosis of co-existent and complicating medical illnesses; b) a current diagnosis of mood disorder, anxiety disorder, eating disorder, or substance addiction disorder; c) relapse after previous detoxification treatment; d) social and environmental problems; e) daily use of multiple doses of symptomatic medications. Group A (46 patients) received only intensive advice to withdraw the overused medication/s. Group B (46 patients) underwent a standard detoxification programme as outpatients (advice+steroids+preventive treatment). Group C (45 patients) underwent a standard inpatient withdrawal programme (advice+steroids+fluid replacement and antiemetics preventive treatment). Withdrawal therapy was considered successful if, after two months, the patient had reverted to an intake of NSAIDs lower than 15 days/month or to an intake of other symptomatic medication/s lower than 10 days/month. Twenty-two patients failed to attend follow-up visits (11 in Group A, 9 in Group B, 2 in Group C, p

Original languageEnglish
Pages (from-to)10
Number of pages1
JournalJournal of Headache and Pain
Volume14
Issue number1
DOIs
Publication statusPublished - Dec 2013

ASJC Scopus subject areas

  • Medicine(all)

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