Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome

Joceline C F Sá, Eduardo C. Costa, Ester Da Silva, Nayara Y. Tamburús, Alberto Porta, Leany F. Medeiros, Telma M A M Lemos, Elvira M M Soares, George D. Azevedo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods Thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p <0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p <0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p <0.05). All parameters remained unchanged in the control group. Conclusions Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalInternational Journal of Cardiology
Volume202
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Polycystic Ovary Syndrome
Exercise
Testosterone
Fasting
Heart Rate
Insulin
Blood Pressure
Control Groups
Supine Position
Entropy
Body Mass Index
Multivariate Analysis

Keywords

  • Aerobic exercise
  • Autonomic nervous system
  • Cardiac autonomic modulation
  • Complexity
  • Heart rate variability
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sá, J. C. F., Costa, E. C., Da Silva, E., Tamburús, N. Y., Porta, A., Medeiros, L. F., ... Azevedo, G. D. (2016). Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome. International Journal of Cardiology, 202, 356-361. https://doi.org/10.1016/j.ijcard.2015.09.031

Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome. / Sá, Joceline C F; Costa, Eduardo C.; Da Silva, Ester; Tamburús, Nayara Y.; Porta, Alberto; Medeiros, Leany F.; Lemos, Telma M A M; Soares, Elvira M M; Azevedo, George D.

In: International Journal of Cardiology, Vol. 202, 01.01.2016, p. 356-361.

Research output: Contribution to journalArticle

Sá, JCF, Costa, EC, Da Silva, E, Tamburús, NY, Porta, A, Medeiros, LF, Lemos, TMAM, Soares, EMM & Azevedo, GD 2016, 'Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome', International Journal of Cardiology, vol. 202, pp. 356-361. https://doi.org/10.1016/j.ijcard.2015.09.031
Sá, Joceline C F ; Costa, Eduardo C. ; Da Silva, Ester ; Tamburús, Nayara Y. ; Porta, Alberto ; Medeiros, Leany F. ; Lemos, Telma M A M ; Soares, Elvira M M ; Azevedo, George D. / Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome. In: International Journal of Cardiology. 2016 ; Vol. 202. pp. 356-361.
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abstract = "Background This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods Thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V{\%}, 1 V{\%}, 2LV{\%}, and 2UV{\%}) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV{\%}; (p <0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V{\%}; (p <0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p <0.05). All parameters remained unchanged in the control group. Conclusions Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.",
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AU - Costa, Eduardo C.

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AU - Porta, Alberto

AU - Medeiros, Leany F.

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AU - Soares, Elvira M M

AU - Azevedo, George D.

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N2 - Background This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods Thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p <0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p <0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p <0.05). All parameters remained unchanged in the control group. Conclusions Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.

AB - Background This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods Thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p <0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p <0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p <0.05). All parameters remained unchanged in the control group. Conclusions Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.

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