Aerobic training and angiogenesis activation in patients with stable chronic heart failure: A preliminary report

Ermanno Eleuteri, Alessandro Mezzani, Antonino Di Stefano, Davide Vallese, Isabella Gnemmi, Lorena Delle Donne, Adriano Taddeo, Silvia Della Bella, Pantaleo Giannuzzi

Research output: Contribution to journalArticle


The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
Issue number5
Publication statusPublished - Aug 2013



  • Cardiovascular disease
  • Growth factors/cytokines/inflammatory mediators
  • Sports science/exercise

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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