Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients

V. Fetoni, D. Testa, S. Genitrini, P. Soliveri, D. Monza, T. Caraceni, F. Girotti

Research output: Contribution to journalArticle


The aim of this study was to assess motor and affective fluctuations in PD and striatonigral degeneration (SND)type MSA patients. We evaluated 10 patients with PD and 10 probable SNDtype MSA patients in the absence of L-dopa therapy and after the administration of 250 mg L-dopa + carbidopa with the following scales: UPDRS for motor assessment, MMSE for mental state, BPRS for psychiatric disturbances, Beck and the Hamilton scales for depression. In basal conditions the UPDRS score was significantly higher in MSA than PD patients, while Beck, Hamilton, MMSE and BPRS did not differ between groups. Beck and Hamilton scores were in the depression range for the two groups. After L-dopa UPDRS, Beck and Hamilton scores improved significantly in PD while BPRS and MMSE did not change. No parameters improved significantly in the MSA patients as a group after L-dopa. This preliminary study shows that depression may be as common in MSA as in PD, where it is recognised as a fluctuating phenomenon. In addition MSA patients are more compromised on depression scale subitems assessing inhibition and affective sensitivity.

Original languageEnglish
Pages (from-to)129
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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