Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients

V. Fetoni, D. Testa, S. Genitrini, P. Soliveri, D. Monza, T. Caraceni, F. Girotti

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess motor and affective fluctuations in PD and striatonigral degeneration (SND)type MSA patients. We evaluated 10 patients with PD and 10 probable SNDtype MSA patients in the absence of L-dopa therapy and after the administration of 250 mg L-dopa + carbidopa with the following scales: UPDRS for motor assessment, MMSE for mental state, BPRS for psychiatric disturbances, Beck and the Hamilton scales for depression. In basal conditions the UPDRS score was significantly higher in MSA than PD patients, while Beck, Hamilton, MMSE and BPRS did not differ between groups. Beck and Hamilton scores were in the depression range for the two groups. After L-dopa UPDRS, Beck and Hamilton scores improved significantly in PD while BPRS and MMSE did not change. No parameters improved significantly in the MSA patients as a group after L-dopa. This preliminary study shows that depression may be as common in MSA as in PD, where it is recognised as a fluctuating phenomenon. In addition MSA patients are more compromised on depression scale subitems assessing inhibition and affective sensitivity.

Original languageEnglish
Pages (from-to)129
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

Fingerprint

Multiple System Atrophy
Mood Disorders
Parkinson Disease
Levodopa
Depression
Striatonigral Degeneration
Carbidopa
Psychiatry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Fetoni, V., Testa, D., Genitrini, S., Soliveri, P., Monza, D., Caraceni, T., & Girotti, F. (1997). Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients. Italian Journal of Neurological Sciences, 18(4), 129.

Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients. / Fetoni, V.; Testa, D.; Genitrini, S.; Soliveri, P.; Monza, D.; Caraceni, T.; Girotti, F.

In: Italian Journal of Neurological Sciences, Vol. 18, No. 4, 1997, p. 129.

Research output: Contribution to journalArticle

Fetoni, V, Testa, D, Genitrini, S, Soliveri, P, Monza, D, Caraceni, T & Girotti, F 1997, 'Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients', Italian Journal of Neurological Sciences, vol. 18, no. 4, pp. 129.
Fetoni, V. ; Testa, D. ; Genitrini, S. ; Soliveri, P. ; Monza, D. ; Caraceni, T. ; Girotti, F. / Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients. In: Italian Journal of Neurological Sciences. 1997 ; Vol. 18, No. 4. pp. 129.
@article{3c5292c49ec14c11a29048c1c2651509,
title = "Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients",
abstract = "The aim of this study was to assess motor and affective fluctuations in PD and striatonigral degeneration (SND)type MSA patients. We evaluated 10 patients with PD and 10 probable SNDtype MSA patients in the absence of L-dopa therapy and after the administration of 250 mg L-dopa + carbidopa with the following scales: UPDRS for motor assessment, MMSE for mental state, BPRS for psychiatric disturbances, Beck and the Hamilton scales for depression. In basal conditions the UPDRS score was significantly higher in MSA than PD patients, while Beck, Hamilton, MMSE and BPRS did not differ between groups. Beck and Hamilton scores were in the depression range for the two groups. After L-dopa UPDRS, Beck and Hamilton scores improved significantly in PD while BPRS and MMSE did not change. No parameters improved significantly in the MSA patients as a group after L-dopa. This preliminary study shows that depression may be as common in MSA as in PD, where it is recognised as a fluctuating phenomenon. In addition MSA patients are more compromised on depression scale subitems assessing inhibition and affective sensitivity.",
author = "V. Fetoni and D. Testa and S. Genitrini and P. Soliveri and D. Monza and T. Caraceni and F. Girotti",
year = "1997",
language = "English",
volume = "18",
pages = "129",
journal = "Italian Journal of Neurological Sciences",
issn = "0392-0461",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Affective disorders in multisystem atrophy (MSA) and Parkinson's disease (PD) patients

AU - Fetoni, V.

AU - Testa, D.

AU - Genitrini, S.

AU - Soliveri, P.

AU - Monza, D.

AU - Caraceni, T.

AU - Girotti, F.

PY - 1997

Y1 - 1997

N2 - The aim of this study was to assess motor and affective fluctuations in PD and striatonigral degeneration (SND)type MSA patients. We evaluated 10 patients with PD and 10 probable SNDtype MSA patients in the absence of L-dopa therapy and after the administration of 250 mg L-dopa + carbidopa with the following scales: UPDRS for motor assessment, MMSE for mental state, BPRS for psychiatric disturbances, Beck and the Hamilton scales for depression. In basal conditions the UPDRS score was significantly higher in MSA than PD patients, while Beck, Hamilton, MMSE and BPRS did not differ between groups. Beck and Hamilton scores were in the depression range for the two groups. After L-dopa UPDRS, Beck and Hamilton scores improved significantly in PD while BPRS and MMSE did not change. No parameters improved significantly in the MSA patients as a group after L-dopa. This preliminary study shows that depression may be as common in MSA as in PD, where it is recognised as a fluctuating phenomenon. In addition MSA patients are more compromised on depression scale subitems assessing inhibition and affective sensitivity.

AB - The aim of this study was to assess motor and affective fluctuations in PD and striatonigral degeneration (SND)type MSA patients. We evaluated 10 patients with PD and 10 probable SNDtype MSA patients in the absence of L-dopa therapy and after the administration of 250 mg L-dopa + carbidopa with the following scales: UPDRS for motor assessment, MMSE for mental state, BPRS for psychiatric disturbances, Beck and the Hamilton scales for depression. In basal conditions the UPDRS score was significantly higher in MSA than PD patients, while Beck, Hamilton, MMSE and BPRS did not differ between groups. Beck and Hamilton scores were in the depression range for the two groups. After L-dopa UPDRS, Beck and Hamilton scores improved significantly in PD while BPRS and MMSE did not change. No parameters improved significantly in the MSA patients as a group after L-dopa. This preliminary study shows that depression may be as common in MSA as in PD, where it is recognised as a fluctuating phenomenon. In addition MSA patients are more compromised on depression scale subitems assessing inhibition and affective sensitivity.

UR - http://www.scopus.com/inward/record.url?scp=33746368742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746368742&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33746368742

VL - 18

SP - 129

JO - Italian Journal of Neurological Sciences

JF - Italian Journal of Neurological Sciences

SN - 0392-0461

IS - 4

ER -