Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a

Tommaso Mazza, Stefano Castellana, Angelo Andriulli, Charles Auffray, Manlio Vinciguerra, Valerio Pazienza

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chronic hepatitis C patients display many genotype-specific clinical features of HCV infection. The core proteins encoded by different genotypes dysregulate numerous sets of distinct host genes. In this study we tested the hypothesis that HCV core proteins 1b and 3a would actually act on a limited number of independent cellular players, as well as on several functionally linked gene products. Structural and functional tests identified a core set of host genes dysregulated by HCV core genotypes 1b and 3a. The core proteins of HCV genotypes 1b and 3a target specifically limited sets of functionally related gene products, which may be responsible for the variations in the clinical spectra associated with HCV infection.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalBioSystems
Volume114
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Genotype
Affine transformation
Hepatocytes
Genes
Gene
Proteins
Protein
Infection
Chronic Hepatitis C
Distinct
Target
Hepatitis C virus nucleocapsid protein

Keywords

  • HCV core protein
  • System biology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics
  • Modelling and Simulation
  • Statistics and Probability
  • Medicine(all)

Cite this

Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a. / Mazza, Tommaso; Castellana, Stefano; Andriulli, Angelo; Auffray, Charles; Vinciguerra, Manlio; Pazienza, Valerio.

In: BioSystems, Vol. 114, No. 1, 2013, p. 64-68.

Research output: Contribution to journalArticle

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