Aflatoxin B1 and M1: Biological properties and their involvement in cancer development

Silvia Marchese, Andrea Polo, Andrea Ariano, Salvatore Velotto, Susan Costantini, Lorella Severino

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Aflatoxins are fungal metabolites found in feeds and foods. When the ruminants eat feedstuffs containing Aflatoxin B1 (AFB1), this toxin is metabolized and Aflatoxin M1 (AFM1) is excreted in milk. International Agency for Research on Cancer (IARC) classified AFB1 and AFM1 as human carcinogens belonging to Group 1 and Group 2B, respectively, with the formation of DNA adducts. In the last years, some epidemiological studies were conducted on cancer patients aimed to evaluate the effects of AFB1 and AFM1 exposure on cancer cells in order to verify the correlation between toxin exposure and cancer cell proliferation and invasion. In this review, we summarize the activation pathways of AFB1 and AFM1 and the data already reported in literature about their correlation with cancer development and progression. Moreover, considering that few data are still reported about what genes/proteins/miRNAs can be used as damage markers due to AFB1 and AFM1 exposure, we performed a bioinformatic analysis based on interaction network and miRNA predictions to identify a panel of genes/proteins/miRNAs that can be used as targets in further studies for evaluating the effects of the damages induced by AFB1 and AFM1 and their capacity to induce cancer initiation.

Original languageEnglish
Article number214
JournalToxins
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Aflatoxin M1
Aflatoxin B1
MicroRNAs
Neoplasms
International Agencies
Aflatoxins
DNA Adducts
Cell proliferation
Ruminants
Bioinformatics
Metabolites
Computational Biology
Carcinogens
Epidemiologic Studies
Milk
Proteins
Chemical activation
Cells
Cell Proliferation
Food

Keywords

  • AFB1
  • Aflatoxin
  • AFM1
  • Cancer

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Aflatoxin B1 and M1 : Biological properties and their involvement in cancer development. / Marchese, Silvia; Polo, Andrea; Ariano, Andrea; Velotto, Salvatore; Costantini, Susan; Severino, Lorella.

In: Toxins, Vol. 10, No. 6, 214, 01.06.2018.

Research output: Contribution to journalReview article

Marchese, Silvia ; Polo, Andrea ; Ariano, Andrea ; Velotto, Salvatore ; Costantini, Susan ; Severino, Lorella. / Aflatoxin B1 and M1 : Biological properties and their involvement in cancer development. In: Toxins. 2018 ; Vol. 10, No. 6.
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