Age-adjusted validation of the most stringent criteria for active surveillance in low-risk prostate cancer patients

Nazareno Suardi, Andrea Gallina, Umberto Capitanio, Andrea Salonia, Giovanni Lughezzani, Massimo Freschi, Alexander Mottrie, Patrizio Rigatti, Francesco Montorsi, Alberto Briganti

Research output: Contribution to journalArticle

Abstract

Background: The authors tested the performance of the currently used clinical criteria reported in populations studied by van den Bergh et al and Carter et al for the selection of patients with prostate cancer (PCa) for active surveillance (AS) according to age. Methods: Data were analyzed from 893 patients who underwent with radical prostatectomy (RP). The authors investigated the rates of unfavorable PCa at RP (extracapsular extension, seminal vesicle or lymph node invasion, or Gleason score 7-10) in patients who fulfilled AS criteria according to age tertiles (ages ≥63 years, 63.1 to 69 years, and >69 years). Area under the plasma concentration time curve (AUC) analyses tested the criteria for predicting unfavorable PCa. Then, the patients were stratified according to the cutoff age of 70 years. Multivariate analyses were used to test the role of age in predicting unfavorable PCa. Results: The rate of unfavorable PCa characteristics was between 24% and 27.8%. In the van den Bergh et al population, after age 70 years, the rate of unfavorable PCa characteristics was 41% compared with 23.2% and 24.1% in patients in the previous age tertiles (ages ≥63 years and 63.1 to 69 years, respectively). In the Carter et al population, the rate of unfavorable PCa was 41.2% compared with 17.3% and 18.6% in the previous age tertiles (ages ≥63 years and 63.1 to 69 years, respectively). When the 70-year age cutoff was used, unfavorable PCa was identified in 17.9% to 23.6% of patients aged 70 years (all P

Original languageEnglish
Pages (from-to)973-980
Number of pages8
JournalCancer
Volume118
Issue number4
DOIs
Publication statusPublished - Feb 15 2012

Keywords

  • active surveillance
  • age
  • prostate cancer
  • radical prostatectomy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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