Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: Effects on long-term T-cell reconstitution

Joanna Lewis, A. Sarah Walker, Hannah Castro, Anita De Rossi, Diana M. Gibb, Carlo Giaquinto, Nigel Klein, Robin Callard

Research output: Contribution to journalArticlepeer-review

Abstract

Background.Effective therapies and reduced AIDS-related morbidity and mortality have shifted the focus in pediatric human immunodeficiency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. We describe the effects of children's age and pre-antiretroviral therapy (ART) CD4 count on long-term CD4 T-cell reconstitution.Methods.CD4 counts in perinatally HIV-infected, therapy-naive children in the Paediatric European Network for the Treatment of AIDS 5 trial were monitored following initiation of ART for a median 5.7 years. In a substudy, naive and memory CD4 counts were recorded. Age-standardized measurements were analyzed using monophasic, asymptotic nonlinear mixed-effects models.Results.One hundred twenty-seven children were studied. Older children had lower age-adjusted CD4 counts in the long term and at treatment initiation (P

Original languageEnglish
Pages (from-to)548-556
Number of pages9
JournalJournal of Infectious Diseases
Volume205
Issue number4
DOIs
Publication statusPublished - Feb 15 2012

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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