Age- and concentration-dependent elimination half-life of 2,3,7,8,-tetrachlorodibenzo-p-dioxin in Seveso children

Brent D. Kerger, Hon Wing Leung, Paul Scott, Dennis J. Paustenbach, Larry L. Needham, Donald G. Patterson, Pier M. Gerthoux, Paolo Mocarelli

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective: Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. Design: We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical analysis include age, latency from exposure, sex, TCDD concentration and quantity in the body, severity of chloracne response, body mass index, and body fat mass. Participants: Blood was collected from 1976 to 1993 from residents of Seveso, Italy, who were <18 years of age at the time of a nearby trichlorophenol reactor explosion in July 1976. Results: TCDD half-life in persons <18 years of age averaged 1.6 years while those ≥ 18 years of age averaged 3.2 years. Half-life is strongly associated with age, showing a cohort average increase of 0.12 year half-life per year of age or time since exposure. A significant concentration-dependency is also identified, showing shorter half-lives for TCDD concentrations > 400 ppt for children <12 years of age and 700 ppt when including adults. Moderate correlations are also observed between half-life and body mass index, body fat mass, TCDD mass, and chloracne response. Conclusions: Children and adolescents have shorter TCDD half-lives and a slower rate of increase in half-life than adults, and this effect is augmented at higher body burdens. Relevance: Modeling of TCDD blood concentrations or body burden in humans should take into account the markedly shorter elimination half-life observed in children and adolescents and concentration-dependent effects observed in persons > 400-700 ppt.

Original languageEnglish
Pages (from-to)1596-1602
Number of pages7
JournalEnvironmental Health Perspectives
Volume114
Issue number10
DOIs
Publication statusPublished - Oct 2006

Fingerprint

dioxin
half life
Half-Life
Chloracne
Blood
blood
Pharmacokinetics
body mass
Italy
fat
Adipose Tissue
Statistical methods
statistical analysis
Body Mass Index
Fats
Polychlorinated Dibenzodioxins
1,4-dioxin
exposure
index
pharmacokinetics

Keywords

  • Children
  • Dioxin
  • Elimination
  • Half-life
  • Model
  • Pharmacokinetics

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Kerger, B. D., Leung, H. W., Scott, P., Paustenbach, D. J., Needham, L. L., Patterson, D. G., ... Mocarelli, P. (2006). Age- and concentration-dependent elimination half-life of 2,3,7,8,-tetrachlorodibenzo-p-dioxin in Seveso children. Environmental Health Perspectives, 114(10), 1596-1602. https://doi.org/10.1289/ehp.8884

Age- and concentration-dependent elimination half-life of 2,3,7,8,-tetrachlorodibenzo-p-dioxin in Seveso children. / Kerger, Brent D.; Leung, Hon Wing; Scott, Paul; Paustenbach, Dennis J.; Needham, Larry L.; Patterson, Donald G.; Gerthoux, Pier M.; Mocarelli, Paolo.

In: Environmental Health Perspectives, Vol. 114, No. 10, 10.2006, p. 1596-1602.

Research output: Contribution to journalArticle

Kerger, BD, Leung, HW, Scott, P, Paustenbach, DJ, Needham, LL, Patterson, DG, Gerthoux, PM & Mocarelli, P 2006, 'Age- and concentration-dependent elimination half-life of 2,3,7,8,-tetrachlorodibenzo-p-dioxin in Seveso children', Environmental Health Perspectives, vol. 114, no. 10, pp. 1596-1602. https://doi.org/10.1289/ehp.8884
Kerger, Brent D. ; Leung, Hon Wing ; Scott, Paul ; Paustenbach, Dennis J. ; Needham, Larry L. ; Patterson, Donald G. ; Gerthoux, Pier M. ; Mocarelli, Paolo. / Age- and concentration-dependent elimination half-life of 2,3,7,8,-tetrachlorodibenzo-p-dioxin in Seveso children. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 10. pp. 1596-1602.
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